Overview of Supplementary Dataset on Survival and Dosing in the
Carcinogenic Potency Database
A supplementary dataset provides dosing and
survival data from papers in the general literature and links to
the CPDB. These data have not been published in the Carcinogenic
Potency Database plot format. Results are given for each dose group
in each experiment. The results may be useful to people who want
additional details about each experiment.
The Supplementary Dataset is available in
Tab-separated and Excel formats.
Detailed documentation on individual data fields is
given in: Documentation of
the Fields in the Supplementary Dataset.
Survival information is reported in cpdb.supp.tab (tab-separated) or
cpdb.supp.xls (Excel) for
those experiments in the general literature for which the published
author chose to report survival results. Examples include the
number of animals alive in a dose group that were at terminal
sacrifice, mean and median survival.
Dose information is included in the cpdb.supp.tab (tab-separated) or
dataset, which describes for each dose group in a literature
experiment: the pattern of dosing, the administered dose levels in
units reported in the published paper, and the dose calculated for
For experiments in which the pattern or level of
the administered dose varied during the course of the experiment
(“variable dosing”), this information is provided in
the files cpdb.suppvary.tab (tab-separated)
(Excel). These experiments have a “v” notecode in the
plot of the CPDB for “variable dosing”.
The main CPDB in
tab-separated format can be linked to the Supplementary
There are many blanks throughout the supplementary
dataset because of varying experimental conditions and individual
authors’ choices about what to report in their published
Survival information is reported whenever given in
the published paper as follows:
- Animals per group at start of the experiment.
- Last death: The length of time on test of the last survivor in
the group. A range may be reported if the last death could not be
precisely determined because it was derived from grouped data.
- Number alive in the dose group at the end of the
- Effective number. Either: (1) the number of animals alive at
the time of the first tumor, or if that is not reported, then (2)
the number of animals examined histopathologically. This is the
number used in the CPDB.
- The shortest time unit reported in the published paper is used
(“da”: days, “wk”: weeks, “mo”:
months, “yr”: years).
- Mean survival: Units are time on test, not age. Often not
reported in the published paper.
- Median survival: Units are time on test, not age. Sometimes
only a range is possible. This is often derived from a graph in the
published paper. Often not reported in published paper.
- Mean survival of the tumor-bearing animals in the dose group.
Rarely reported in published paper.
- Median survival of the tumor-bearing animals in the dose group.
Rarely reported in published paper.
- Age at first dose, or for variable dosing, the age at which
each dose began. If weanling is all that is reported in published
paper, 6 weeks is assumed for rats, mice, and hamsters.
The dosing information from the published paper
reported in the supplementary dataset is used in combination with
the standard values for each sex-species to calculate the dose in
mg/kg/day that is used in the CPDB.
- The daily-dose rate averaged over the length of experiment and
reported in the CPDB.
- The type of dosing: control group, regular, variable or total
dose (rarely used)
In regular dosing, the amount and schedule of dosing is fixed and
regular throughout the experiment.
In variable dosing, the dose amount and/or the dosing pattern is
changed during the experiment.
- For inhalation exposures, number of hours per day that animals
are in the chamber.
- For gavage and injection routes, milliliters per exposure when
dose is given in mg/ml in the published paper. For inhalation tests
or tests for which the dose is reported in moles/liter, the
molecular weight is used to calculate the dose in mg/kg/day.
- The dose in units reported in the published paper. Possible
%, mg/kg_eat, mg/kg_weight, mg, mg/ml, moles/liter, ppm, gm,
These dose values are used to calculate the dose in mg/kg/day using
the standard values table for the
- The number of variable doses, if the dose administered to a
group changed during the experiment, or if the pattern of dosing
changed, then the frequency of changes is reported
- The pattern of dose levels for a single dose group when the
dose varies over time.
- The period of time during which the chemical was administered,
e.g. if the animal is exposed 5 times per week for 80 weeks, the
exposure length is 80 weeks.
- The number of times per week of exposure. For dietary
administration, ad libitum feeding is 7 times per week.
- Duration of the experiment to terminal sacrifice.
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Potency Project (CPDB) Home Page:
Last updated: August 6, 2007
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