Margin of Exposure figure
How Many Fold Lower is Human Exposure Than the Dose That Gave Rodents Cancer Margin of Exposure (Rodent Cancer Dose/Human Exposure) Lois Swirsky Gold, Bruce N. Ames, Thomas H. Slone Carcinogenic Potency Project This work was supported by the Department of Energy, Project ID 0012861. Vinyl chloride polymerization workers, 1955-1960 Vinyl chloride EDB: production workers (high exposure before 1977) Ethylene dibromide Clofibrate Clofibrate Vinyl chloride polymerization workers, 1975 Vinyl chloride Phenobarbital, 1 sleeping pill Phenobarbital Gemfibrozil Gemfibrozil Butadiene-styrene rubber industry workers (1978-86) 1,3-Butadiene Formaldehyde: production workers (1979) Formaldehyde Comfrey-pepsin tablets, 9 daily; FDA has issued an advisory against use Comfrey root Acrylonitrile: production workers (1960-1986) Acrylonitrile Diet pills containing Aristolochia fangchi, 2 years Aristolochic acid Tetrachloroethylene: dry cleaners with dry-to-dry units (1980-90) Tetrachloroethylene Alcoholic beverages, all types Ethyl alcohol Vinyl fluoride polymer production workers (1980) Vinyl fluoride Trichloroethylene: vapor degreasing (before 1977) Trichloroethylene Beer Ethyl alcohol Comfrey-pepsin tablets, 9 daily; FDA has issued an advisory against use Symphytine Ethylene oxide: sterilization workers Ethylene oxide Methylene chloride: workers, industry average (1940s-80s) Methylene chloride Dehydroepiandrosterone (DHEA) DHEA supplement Wine Ethyl alcohol Formaldehyde: manufactured home air (12 hours/day) Formaldehyde Fluvastatin Omeprazole Formaldehyde: conventional home air (12 hours/day) Formaldehyde Coffee Caffeic acid d-Limonene in food Mushroom (Agaricus bisporus) Mixture of hydrazines, etc. (whole mushroom) Gasoline station workers (1997) MTBE Lovastatin Lovastatin Bread Ethyl alcohol Lettuce Caffeic acid Comfrey herb tea, 1 cup (1.5 g root); FDA has issued an advisory against use Symphytine Safrole in spices Safrole Tomato Caffeic acid Orange juice d-Limonene Furfural in food Furfural Pepper, black d-Limonene Coffee Catechol Apple Caffeic acid BHA in total diet (1975) BHA Acrylamide in total diet Acrylamide Vinyl acetate production workers (1968) Vinyl acetate Beer (before 1979) Dimethylnitrosamine Aflatoxin in total diet (1984-89) Aflatoxin Celery Caffeic acid d-Limonene Food additive Coffee Furfural Coffee Hydroquinone Saccharin in total diet (1977) Saccharin Potato Caffeic acid Bread Furfural Methyleugenol in food Methyleugenol Cinnamon Coumarin BHA in total diet (1987) Carrot Caffeic acid Nutmeg d-Limonene Coffee 4-Methylcatechol French fries (restaurant) Acrylamide DDT in total diet (before 1972 ban) DDT Ethylene thiourea in total diet (1990) Ethylene thiourea Coffee Acrylamide Pear Caffeic acid French fries (oven baked) Acrylamide Plum Caffeic acid Estragole in spices Estragole Breakfast cereal Acrylamide Mushroom (Agaricus bisporus) Glutamyl-p-hydrazinobenzoate Potato chips Acrylamide Bacon Diethylnitrosamine Allspice Methyleugenol Nutmeg Methyleugenol [UDMH in total diet (1988)] [UDMH (from Alar)] Toxaphene in total diet (before 1982 ban) Toxaphene Professional vehicle drivers (1997) MTBE Bacon Dimethylnitrosamine Benzene: home air (12 hours/day) Benzene Bacon N-Nitrosopyrrolidine DDE in total diet (before 1972 ban) DDE Basil Methyleugenol Tap water, 1 liter (1987-92) Chloroform Basil Estragole Methyleugenol Food additive Celery 8-Methoxypsoralen Tap water, 1 liter (1987-92) Bromodichloromethane Carbaryl in total diet (1990) Carbaryl EDB in total diet (before 1984 ban) b EDB TCDD in total diet (1994) TCDD Mustard Allyl isothiocyanate Furfural Food additive Mango d-Limonene Fennel Estragole Beer (1994-95) Dimethylnitrosamine Canned black olives Acrylamide Hamburger, pan fried PhIP Mushroom (Agaricus bisporus) p-Hydrazinobenzoate Allyl isothiocyanate Food additive Tetrachloroethylene: home air (12 hours/day) Tetrachloroethylene Benzene: outdoor air (2 hours/day) Benzene Estragole Food additive Anise Estragole Toxaphene in total diet (1990) Toxaphene Toast Urethane Beer Furfural DDE/DDT in total diet (1990) DDE Parsnip 8-Methoxypsoralen 1,4-Dichlorobenzene: home air (12 hours/day) 1,4-Dichlorobenzene Tetrachloroethylene: outdoor air (2 hours/day) Tetrachloroethylene PCBs in total diet (1984-86) PCBs Parsley 8-Methoxypsoralen Hamburger, pan fried MeIQx Dicofol in total diet (1990) Dicofol Hamburger, pan fried IQ Beer Urethane 1,4-Dichlorobenzene: outdoor air (2 hours/day) 1,4-Dichlorobenzene Trichloroethylene: home air (12 hours/day) Trichloroethylene Hexachlorobenzene in total diet (1990) b Hexachlorobenzene Banana Methyleugenol Lindane in total diet (1990) Lindane Trichloroethylene: outdoor air (2 hours/day) Trichloroethylene PCNB in total diet (1990) PCNB (Quintozene) Chlorobenzilate in total diet (1989) b Chlorobenzilate Captan in total diet (1990) Captan Folpet in total diet (1990) Folpet Chlorothalonil in total diet (1990) Chlorothalonil cancer potency
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