MOE: Margin of Exposure: First the average human daily intake of rodent carcinogen is divided by 70 kg body weight to give estimated human intake in mg/kg/day. Second, LTD10 is calculated from the Carcinogenic Potency Database as the lower 95% confidence limit on the tumorigenic dose-rate for 10% of rodents (mg/kg/day). Third, MOE is calculated as
|LTD10 in the
Human exposure (mg/kg/day)
For statistical methods to estimate LTD10, see ltd10.html.
The example below is for the naturally-occurring chemical acrylamide, which is formed by cooking starch-rich foods at high temperature. In the graphic and the table, the MOE is reported for the total intake of acrylamide in the average US diet and also for consumption of just French fried potatoes in restaurants.
|MOE (LTD10/Human Exposure)||Average Daily US Exposure||Human Intake of Rodent Carcinogen
Amount per Day [Amount in mg/kg/day]
|Rodent Cancer Dose LTD10 [mg/kg/day]||References for Human Exposure|
|900||Acrylamide in total diet||Acrylamide, 28 µg [0.0004 mg/kg/day]||0.365||.||(DiNovi and Howard 2004)|
|6,000||French fries (restaurant), 12.2 g||Acrylamide, 4.06 µg [0.000058 mg/kg/day]||0.365||.||(DiNovi and Howard 2004)|
Both the average concentration of acrylamide in restaurant French fries (333 µg/kg = 0.333 ppm) and the average US consumption of French fries in restaurants (12.2 gm/day) are used, and are from the reference.
Consumption of the food (gm/day) × Chemical concentration (ppm) = Exposure of chemical (µg/day)
12.2 gm/day × 0.333 ppm = 4.06 µg/day
The consumption of acrylamide in French fries in mg/day is as follows:
Return to the Carcinogenic Potency Project (CPDB) Home Page:
Last updated: September 25, 2008