|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|Hamster Target Sites||TD50
|no positive||no positive||no positive|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
3-AMINOTRIAZOLE (amitrol) 61-82-5 359 H f syg eat 28m28 1557o 0 .105mg 1.05mg 10.5mg Steinhoff;txap,69,161-169;1983 lun tum ae no dre P=1. 2.00mg n.s.s. 0/76 0/76 0/76 0/76 liv ben ae no dre P=1. - 242.mg n.s.s. 1/76 1/76 0/76 0/76 tba mix ae no dre P=1. - 59.5mg n.s.s. 13/76 10/76 12/76 11/76 tba mal ae 570.mg * P<.6 - 81.3mg n.s.s. 1/76 2/76 3/76 3/76 360 H m syg eat 31m32 1557o 0 92.0ug .920mg 9.20mg liv ben ae no dre P=1. - 2.29mg n.s.s. 0/76 0/76 0/76 0/75 lun tum ae no dre P=1. 2.29mg n.s.s. 0/76 0/76 0/76 0/75 tba mix ae no dre P=1. - 85.6mg n.s.s. 20/76 11/76 13/76 11/75 tba mal ae no dre P=1. - 160.mg n.s.s. 7/76 2/76 5/76 2/75 361 M f b6a orl 59w59 35a 0 321.mg Innes;ntis,1968/1969 liv hpt evx 24.5mg P<.0005 + 9.88mg 58.2mg 0/17 17/18 lun mix evx no dre P=1. 384.mg n.s.s. 0/17 0/18 tba mix evx 25.6mg P<.0005 10.0mg 66.8mg 2/17 17/18 362 M m b6a orl 52w52 35a 0 306.mg liv hpt evx 26.0mg P<.0005 + 11.5mg 72.3mg 3/18 16/18 lun ade evx no dre P=1. 283.mg n.s.s. 2/18 0/18 tba mix evx 28.0mg P<.0005 11.8mg 98.4mg 5/18 16/18 363 M f b6c orl 57w57 35a 0 323.mg liv hpt evx noTD50 P<.0005 n.s.s. 37.3mg 0/18 18/18 lun ade evx no dre P=1. 359.mg n.s.s. 1/18 0/18 tba mix evx noTD50 P<.0005 n.s.s. 42.2mg 3/18 18/18 364 M m b6c orl 53w53 35a 0 305.mg liv hpt evx 25.4mg P<.0005 + 11.6mg 61.4mg 1/17 16/18 lun ade evx no dre P=1. 294.mg n.s.s. 2/17 0/18 tba mix evx 30.8mg P<.002 12.5mg 146.mg 6/17 16/18 365 M f nmr eat 33m33 1557n 0 .130mg 1.30mg 13.0mg Steinhoff;txap,69,161-169;1983 liv tum ae no dre P=1. - 3.29mg n.s.s. 0/73 0/73 0/74 0/74 lun tum ae no dre P=1. 3.29mg n.s.s. 0/73 0/73 0/74 0/74 tba mal ae 6.92mg Z P<.2 - 2.32mg n.s.s. 46/73 26/73 46/74 (38/74) tba mix ae no dre P=1. - 26.3mg n.s.s. 60/73 48/73 59/74 55/74 366 M m nmr eat 34m34 1557n 0 .120mg 1.20mg 12.0mg liv mal ae 2.76gm * P<.8 - 200.mg n.s.s. 1/75 0/73 1/73 1/72 lun tum ae no dre P=1. 3.20mg n.s.s. 0/75 0/73 0/73 0/72 tba mal ae 347.mg * P<.7 - 41.1mg n.s.s. 27/75 38/73 26/73 32/72 tba mix ae no dre P=1. - 43.7mg n.s.s. 52/75 56/73 47/73 46/72 367 R b nss eat 24m24 1513 0 .450mg 2.25mg 4.50mg Jukes;scie,132,296-297;1960 thy ade er 3.74mg * P<.0005 2.17mg 8.86mg 0/5 1/10 2/15 17/26 368 R f wis wat 16m24 35 0 96.2mg Tsuda;jnci,57,861-864;1976 tyf mal r 102.mg P<.002 58.9mg 299.mg 0/10 19/40 369 R f wis eat 38m38 1557m 0 50.0ug .500mg 5.00mg Steinhoff;txap,69,161-169;1983 thy ben ae 11.5mg * P<.0005 + 7.53mg 19.8mg 7/74 12/75 8/75 44/75 thy mal ae 17.7mg * P<.0005 + 11.4mg 30.1mg 0/74 1/75 4/75 28/75 pit ben ae 20.8mg * P<.0005 + 11.3mg 61.3mg 14/74 20/75 15/75 36/75 liv tum ae no dre P=1. 1.71mg n.s.s. 0/74 0/75 0/75 0/75 tba mix ae 7.55mg * P<.01 3.11mg 626.mg 59/74 67/75 60/75 71/75 tba mal ae 17.7mg * P<.0005 9.13mg 73.9mg 20/74 34/75 29/75 45/75 370 R m wis eat 38m38 1557m 0 40.0ug .400mg 4.00mg thy ben ae 8.75mg Z P<.0005 + 5.85mg 14.2mg 5/75 9/74 4/75 45/75 thy mal ae 27.0mg * P<.0005 + 15.2mg 60.5mg 3/75 0/74 3/75 18/75 liv hpc ae no dre P=1. 115.mg n.s.s. 0/75 0/74 1/75 0/75 tba mix ae 13.8mg * P<.009 6.31mg 441.mg 36/75 41/74 44/75 53/75 tba mal ae 135.mg * P<.6 21.4mg n.s.s. 19/75 20/74 23/75 23/75
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.