|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|ezy liv lun mgl vsc||liv lun mgl||no test||no test||19.3m||no test|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
4,4'-METHYLENE-BIS(2-CHLOROANILINE) (3,3'-dichloro-4,4'-diaminodiphenylmethane, MOCA) 101-14-4 3899 D f beg eat 9y9 1030 0 7.31mg Stula;jept,1,31-50;1977 ubl ptc emv 2.12mg P<.003 + .586mg 14.8mg 0/6 4/5 liv hnd emv 3.72mg P<.02 + 1.04mg n.s.s. 0/6 3/5 mgl mix emv no dre P=1. - 2.29mg n.s.s. 4/6 2/5 3900 R f cdr eat 67w67 192m 0 50.0mg Stula;txap,31,159-176;1975/pers.comm. lun adc ef 42.3mg P<.003 + 17.1mg 223.mg 0/21 6/21 mgl adc ef 42.3mg P<.003 + 17.1mg 223.mg 0/21 6/21 liv hpa ef 142.mg P<.1 - 34.9mg n.s.s. 0/21 2/21 liv hpc ef 291.mg P<.3 - 47.4mg n.s.s. 0/21 1/21 3901 R f cdr eat 24m24 192n 0 50.0mg lun adc e 34.7mg P<.0005 + 21.4mg 60.5mg 0/44 27/44 liv hpc e 467.mg P<.04 - 141.mg n.s.s. 0/44 3/44 liv hpa e 708.mg P<.1 - 174.mg n.s.s. 0/44 2/44 liv cho e 1.43gm P<.3 - 233.mg n.s.s. 0/44 1/44 3902 R m cdr eat 67w67 192m 0 40.0mg liv hpc ef 15.3mg P<.0005 + 7.53mg 38.0mg 0/21 11/21 liv hpa ef 41.8mg P<.007 + 15.8mg 498.mg 0/21 5/21 lun adc ef 41.8mg P<.007 + 15.8mg 498.mg 0/21 5/21 3903 R m cdr eat 24m24 192n 0 40.0mg lun adc e 42.3mg P<.0005 + 25.0mg 79.2mg 0/44 21/44 liv hpc e 388.mg P<.04 - 117.mg n.s.s. 0/44 3/44 liv hpa e 388.mg P<.04 - 117.mg n.s.s. 0/44 3/44 3904 R m cdr eat 18m24 1031m 0 7.53mg 15.1mg 34.0mg Kommineni;jept,2,149-171;1979 lun neo es 20.8mg * P<.0005 + 15.7mg 28.6mg 1/100 23/100 28/75 35/50 lun mix es 29.2mg * P<.0005 + 21.5mg 41.1mg 0/100 14/100 20/75 31/50 mgl adc es 87.6mg * P<.0005 + 53.7mg 174.mg 1/100 5/100 8/75 14/50 liv hpc es 92.2mg Z P<.0005 + 56.8mg 164.mg 0/100 3/100 3/75 18/50 zym car es 107.mg * P<.0005 + 61.4mg 288.mg 1/100 8/100 5/75 11/50 --- ker es 144.mg Z P<.01 63.9mg 6.58gm 1/100 3/100 7/75 (1/50) ski sqc es 286.mg * P<.2 109.mg n.s.s. 1/100 4/100 7/75 2/50 tba mix es 10.4mg * P<.0005 6.48mg 21.1mg 58/100 80/100 61/75 48/50 3905 R m cdr eat 18m24 1031n 0 3.76mg 7.53mg 15.1mg lun neo efs 35.1mg * P<.0005 + 22.7mg 58.9mg 0/100 6/100 11/75 13/50 lun mix efs 60.9mg * P<.0005 + 35.0mg 127.mg 0/100 3/100 7/75 8/50 zym car efs 112.mg * P<.0005 + 54.5mg 298.mg 0/100 0/100 4/75 6/50 liv hpc efs 124.mg Z P<.0005 + 58.3mg 337.mg 0/100 0/100 0/75 9/50 mgl adc efs 162.mg * P<.006 + 70.1mg 1.51gm 0/100 1/100 3/75 3/50 --- hes efs 138.mg * P<.02 + 58.8mg n.s.s. 1/100 2/100 4/75 4/50 ski sqc efs 263.mg * P<.03 90.3mg n.s.s. 1/100 0/100 1/75 4/50 tba mix efs 14.8mg * P<.0005 8.87mg 37.5mg 37/100 34/100 40/75 36/50 3906 R f wi2 eat 16m28 1018 0 29.9mg Grundmann;zkko,74,28-39;1970 liv mix e 15.8mg P<.0005 + 8.23mg 32.9mg 0/25 18/22 mgl mix e 51.4mg P<.003 22.5mg 352.mg 2/25 10/22 lun mix e 104.mg P<.005 + 39.4mg 827.mg 0/25 5/22 tba mix e 11.6mg P<.0005 + 5.53mg 25.9mg 2/25 20/22 3907 R m wi2 eat 16m30 1018 0 22.5mg liv mix e 10.8mg P<.0005 + 5.69mg 21.6mg 0/25 22/25 lun mix e 59.5mg P<.0005 + 26.8mg 192.mg 0/25 8/25 tba mix e 9.09mg P<.0005 + 4.52mg 18.4mg 0/25 23/25
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.