|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|liv thy||thy||adr liv thy||hmo liv thy||20m||32.4m|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
4,4'-METHYLENEDIANILINE.2HCl 13552-44-8 3946 M f b6c wat 24m24 TR248 : 0 29.4mg 59.1mg MXB MXB 32.6mg * P<.0005 19.1mg 95.5mg 16/50 36/50 44/50 ---:mlh,mlm,mlu,mno; liv:hpa,hpc; thy:fca. C liv MXA 59.3mg * P<.0005 c 35.2mg 162.mg 4/50 15/50 23/50 liv:hpa,hpc. --- MXA 64.7mg * P<.007 c 32.7mg 1.16gm 13/50 28/50 29/50 ---:mlh,mlm,mlu,mno. thy MXA 128.mg / P<.0005 71.6mg 265.mg 0/50 1/50 15/50 thy:fca,fcc. S liv hpc 137.mg * P<.002 c 72.0mg 611.mg 1/50 6/50 11/50 thy fca 150.mg / P<.0005 c 80.7mg 338.mg 0/50 1/50 13/50 liv hpa 135.mg * P<.02 c 65.1mg n.s.s. 3/50 9/50 12/50 lun MXA 268.mg * P<.04 109.mg n.s.s. 2/50 3/50 8/50 lun:a/a,a/c. S lun a/a 327.mg * P<.04 129.mg n.s.s. 1/50 2/50 6/50 S TBA MXB 52.1mg * P<.05 22.1mg n.s.s. 32/50 47/50 47/50 liv MXB 59.3mg * P<.0005 35.2mg 162.mg 4/50 15/50 23/50 liv:hpa,hpc,nnd. lun MXB 268.mg * P<.04 109.mg n.s.s. 2/50 3/50 8/50 lun:a/a,a/c. 3947 M m b6c wat 24m24 TR248 : 0 24.5mg 49.5mg liv MXA 17.0mg \ P<.0005 9.07mg 65.8mg 17/50 43/50 (37/50) liv:hpa,hpc. S liv hpc 22.3mg \ P<.0005 c 12.1mg 75.5mg 10/50 33/50 (29/50) MXB MXB 28.7mg * P<.0005 17.1mg 78.7mg 12/50 36/50 34/50 adr:phe; liv:hpc; thy:fca. C adr phe 70.0mg * P<.0005 c 39.7mg 231.mg 2/50 12/50 14/50 thy fca 88.4mg / P<.0005 c 51.4mg 172.mg 0/50 3/50 16/50 TBA MXB 47.4mg * P<.07 19.1mg n.s.s. 37/50 47/50 45/50 liv MXB 17.0mg \ P<.0005 9.07mg 65.8mg 17/50 43/50 (37/50) liv:hpa,hpc,nnd. lun MXB no dre P=1. 168.mg n.s.s. 13/50 12/50 4/50 lun:a/a,a/c. 3948 R f f34 wat 24m24 TR248 : 0 8.41mg 16.7mg thy MXB 22.0mg * P<.0005 13.9mg 38.4mg 0/50 5/50 22/50 thy:cca,fca. C thy MXA 27.2mg * P<.0005 16.6mg 50.3mg 0/50 4/50 19/50 thy:fca,fcc. S thy fca 33.5mg / P<.0005 c 19.5mg 66.1mg 0/50 2/50 17/50 thy cca 73.7mg * P<.007 c 34.7mg 873.mg 0/50 3/50 6/50 thy MXA 70.0mg * P<.04 30.6mg n.s.s. 1/50 5/50 7/50 thy:cca,ccr. S TBA MXB 277.mg * P<1. 10.6mg n.s.s. 43/50 48/50 49/50 liv MXB 118.mg * P<.4 31.5mg n.s.s. 4/50 8/50 8/50 liv:hpa,hpc,nnd. 3949 R m f34 wat 24m24 TR248 : 0 7.36mg 14.7mg MXB MXB 12.5mg * P<.0005 8.33mg 22.0mg 1/50 12/50 29/50 liv:nnd; thy:fcc. C liv nnd 14.3mg * P<.0005 c 9.35mg 27.1mg 1/50 12/50 25/50 thy MXA 49.5mg * P<.006 24.4mg 535.mg 1/50 4/50 10/50 thy:fca,fcc. S thy fcc 85.4mg * P<.003 c 36.9mg 422.mg 0/50 0/50 7/50 TBA MXB no dre P=1. 15.3mg n.s.s. 45/50 42/50 40/50 liv MXB 14.1mg * P<.0005 9.22mg 26.6mg 1/50 13/50 25/50 liv:hpa,hpc,nnd.
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.