|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|no positive||kid||liv lun sto||liv lun sto||424||25.1m|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
BENZOFURAN 271-89-6 661 M f b6c gav 24m24 TR370 : 0 84.9mg 170.mg MXB MXB 33.4mg \ P<.0005 18.8mg 73.8mg 5/50 27/50 (29/50) for:sqc,sqp; liv:hpa; lun:a/a,a/c. C liv hpa 34.4mg \ P<.0005 c 19.7mg 71.5mg 1/50 22/50 (21/50) liv MXA 36.4mg \ P<.0005 20.4mg 80.8mg 4/50 25/50 (22/50) liv:hpa,hpc. S for MXA 145.mg \ P<.003 c 61.8mg 890.mg 2/50 9/50 (5/50) for:sqc,sqp. for sqp 172.mg \ P<.005 69.8mg 1.88gm 2/50 8/50 (5/50) S lun MXA 174.mg * P<.0005 c 98.1mg 449.mg 2/50 9/50 14/50 lun:a/a,a/c. lun a/a 224.mg * P<.0005 122.mg 565.mg 1/50 5/50 13/50 S MXA mlu 322.mg \ P<.04 101.mg n.s.s. 1/50 4/50 (1/50) mul:mlu; spl:mlu. S TBA MXB 45.9mg \ P<.002 22.3mg 255.mg 27/50 35/50 (35/50) liv MXB 36.4mg \ P<.0005 20.4mg 80.8mg 4/50 25/50 (22/50) liv:hpa,hpc,nnd. lun MXB 174.mg * P<.0005 98.1mg 449.mg 2/50 9/50 14/50 lun:a/a,a/c. 662 M m b6c gav 24m24 TR370 : 0 42.4mg 84.9mg liv MXA 19.8mg \ P<.0005 c 10.7mg 52.5mg 12/50 31/50 (40/50) liv:hpa,hpb,hpc. liv hpa 20.5mg \ P<.0005 c 11.5mg 46.9mg 4/50 24/50 (34/50) liv MXA 21.3mg \ P<.0005 11.4mg 58.6mg 12/50 30/50 (37/50) liv:hpa,hpc. S MXB MXB 23.9mg \ P<.002 11.7mg 108.mg 20/50 32/50 (45/50) for:sqc,sqp; liv:hpa,hpb,hpc; lun:a/a,a/c. C liv hpb 102.mg * P<.0005 c 60.1mg 191.mg 0/50 3/50 18/50 for MXA 108.mg * P<.002 c 58.7mg 438.mg 2/50 11/50 13/50 for:sqc,sqp. liv MXA 114.mg * P<.006 55.7mg 1.46gm 9/50 10/50 22/50 liv:hpb,hpc. S lun a/a 136.mg * P<.004 67.8mg 1.08gm 4/50 7/50 15/50 S for sqp 154.mg * P<.007 74.8mg 2.64gm 2/50 7/50 10/50 S lun MXA 160.mg * P<.04 c 67.6mg n.s.s. 10/50 9/50 19/50 lun:a/a,a/c. for sqc 383.mg * P<.03 163.mg n.s.s. 0/50 4/50 3/50 S mul mlp 919.mg * P<.04 272.mg n.s.s. 0/50 0/50 3/50 S TBA MXB 54.3mg * P<.02 25.8mg n.s.s. 29/50 32/50 45/50 liv MXB 21.3mg \ P<.0005 11.4mg 58.6mg 12/50 30/50 (37/50) liv:hpa,hpc,nnd. lun MXB 160.mg * P<.04 67.6mg n.s.s. 10/50 9/50 19/50 lun:a/a,a/c. 663 R f f34 gav 24m24 TR370 : 0 42.4mg 84.9mg sub nlm 98.8mg \ P<.005 42.7mg 939.mg 1/50 9/50 (3/50) S lun MXA 418.mg * P<.04 159.mg n.s.s. 0/50 2/50 3/50 lun:a/a,a/c. S kid uac 424.mg * P<.02 p 161.mg n.s.s. 0/50 1/50 4/50 lun a/a 530.mg * P<.04 183.mg n.s.s. 0/50 1/50 3/50 S ton sqp 574.mg * P<.04 194.mg n.s.s. 0/50 1/50 3/50 S TBA MXB 577.mg * P<.9 40.0mg n.s.s. 46/50 48/50 42/50 liv MXB 2.09gm * P<.3 341.mg n.s.s. 0/50 0/50 1/50 liv:hpa,hpc,nnd. 664 R m f34 gav 24m24 TR370 : 0 21.2mg 42.4mg tes ict # 8.03mg \ P<.004 - 3.77mg 68.2mg 42/50 40/50 (41/50) S pit adn 45.8mg * P<.03 19.5mg n.s.s. 18/50 16/50 22/50 S MXA mnl 55.3mg * P<.02 25.4mg n.s.s. 10/50 13/50 17/50 liv:mnl; mul:mnl. S lun a/c 166.mg * P<.03 60.0mg n.s.s. 0/50 3/50 2/50 S mgl fba 271.mg * P<.03 77.8mg n.s.s. 0/50 0/50 3/50 S thy fcc 389.mg * P<.03 103.mg n.s.s. 0/50 0/50 3/50 S TBA MXB 22.5mg * P<.02 10.4mg n.s.s. 45/50 42/50 46/50 liv MXB no dre P=1. 147.mg n.s.s. 1/50 1/50 0/50 liv:hpa,hpc,nnd.
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.