|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|kid liv||liv thy||liv||liv thy||222m||113m|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
CHLORINATED PARAFFINS (C12, 60% CHLORINE) (chlorowax 500c, avg. mol. wt. = 411) 63449-39-8 1223 M f b6c gav 24m24 TR308 : 0 87.6mg 176.mg MXB MXB 86.8mg * P<.0005 53.3mg 200.mg 11/50 29/50 34/50 liv:hpa,hpc; thy:fca,fcc. C liv MXA 93.8mg * P<.0005 c 62.2mg 169.mg 3/50 22/50 28/50 liv:hpa,hpc. liv hpa 105.mg * P<.0005 c 70.9mg 164.mg 0/50 18/50 22/50 mul mlp 599.mg * P<.002 278.mg 2.56gm 0/50 3/50 6/50 S thy MXA 307.mg * P<.03 c 136.mg n.s.s. 8/50 12/50 15/50 thy:fca,fcc. hag adn 347.mg \ P<.04 126.mg n.s.s. 1/50 6/50 (2/50) S thy fca 372.mg * P<.06 c 150.mg n.s.s. 8/50 12/50 13/50 liv hpc 596.mg * P<.03 247.mg n.s.s. 3/50 4/50 9/50 S TBA MXB 170.mg * P<.2 64.1mg n.s.s. 40/50 42/50 42/50 liv MXB 93.8mg * P<.0005 62.2mg 169.mg 3/50 22/50 28/50 liv:hpa,hpc,nnd. lun MXB no dre P=1. 581.mg n.s.s. 3/50 4/50 1/50 lun:a/a,a/c. 1224 M m b6c gav 24m24 TR308 : 0 87.6mg 177.mg liv MXA 143.mg * P<.006 c 71.9mg 1.83gm 20/50 34/50 38/50 liv:hpa,hpc. liv hpa 157.mg * P<.002 c 83.9mg 811.mg 11/50 20/50 29/50 lun a/c 606.mg * P<.004 284.mg 1.65gm 0/50 3/50 6/50 S TBA MXB 211.mg * P<.2 74.9mg n.s.s. 37/50 44/50 46/50 liv MXB 143.mg * P<.006 71.9mg 1.83gm 20/50 34/50 38/50 liv:hpa,hpc,nnd. lun MXB 851.mg * P<.3 263.mg n.s.s. 5/50 6/50 9/50 lun:a/a,a/c. 1225 R f f34 gav 24m24 TR308 : 0 221.mg 442.mg mul mnl s 345.mg \ P<.009 158.mg 11.0gm 11/50 22/50 (16/50) S MXB MXB s 583.mg * P<.0005 351.mg 1.17gm 0/50 11/50 12/50 liv:hpc,nnd; thy:fca,fcc. C thy fca s 736.mg \ P<.003 290.mg 3.62gm 0/50 6/50 (3/50) S liv MXA s 1.14gm * P<.002 c 577.mg 4.00gm 0/50 5/50 7/50 liv:hpc,nnd. thy MXA s 1.16gm * P<.003 c 592.mg 5.24gm 0/50 6/50 6/50 thy:fca,fcc. liv nnd s 1.20gm * P<.002 c 597.mg 2.94gm 0/50 4/50 7/50 ute MXA s 394.mg \ P<.02 167.mg n.s.s. 6/50 14/50 (11/50) ute:esp,ess. S pan ana s 839.mg \ P<.04 286.mg n.s.s. 1/50 5/50 (2/50) S thy fcc s 4.06gm * P<.04 1.23gm n.s.s. 0/50 0/50 3/50 S TBA MXB s 1.10gm * P<.6 205.mg n.s.s. 48/50 45/50 46/50 liv MXB s 1.14gm * P<.002 577.mg 4.00gm 0/50 5/50 7/50 liv:hpa,hpc,nnd. 1226 R m f34 gav 24m24 TR308 : 0 221.mg 442.mg tes ict s 75.2mg * P<.0005 41.7mg 187.mg 48/50 49/50 47/50 S MXB MXB s 110.mg * P<.0005 61.4mg 202.mg 0/50 18/50 18/50 kid:tla,uac; liv:hpc,nnd. C liv MXA s 123.mg * P<.0005 c 65.6mg 240.mg 0/50 13/50 16/50 liv:hpc,nnd. pan MXA s 144.mg * P<.0005 76.1mg 369.mg 11/50 22/50 17/50 pan:acc,ana. S pan ana s 150.mg * P<.0005 77.5mg 409.mg 11/50 22/50 15/50 S liv nnd s 173.mg * P<.0005 c 88.6mg 335.mg 0/50 10/50 16/50 adr MXA s 192.mg * P<.0005 88.0mg 864.mg 15/50 15/50 15/50 adr:phe,phm. S kid MXA s 196.mg \ P<.0005 c 75.8mg 591.mg 0/50 9/50 (3/50) kid:tla,uac. MXA mnl s 406.mg * P<.003 169.mg 2.48gm 7/50 12/50 14/50 mul:mnl; spl:mnl. S kid tla s 417.mg * P<.0005 164.mg 1.43gm 0/50 7/50 3/50 S liv hpc s 551.mg * P<.002 184.mg 3.24gm 0/50 3/50 2/50 S MXA fib s 332.mg \ P<.04 90.5mg n.s.s. 3/50 5/50 (1/50) ski:fib; sub:fib. S pre MXA s 522.mg * P<.03 173.mg n.s.s. 9/50 4/50 9/50 pre:adn,can. S mgl fba s 566.mg * P<.03 172.mg n.s.s. 2/50 4/50 2/50 S pre adn s 568.mg * P<.02 183.mg n.s.s. 4/50 3/50 7/50 S TBA MXB s 75.7mg * P<.0005 41.8mg 193.mg 50/50 49/50 48/50 liv MXB s 123.mg * P<.0005 65.6mg 240.mg 0/50 13/50 16/50 liv:hpa,hpc,nnd.
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.