|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|Monkey Target Sites||TD50
|no positive||tba||no positive||0.0701|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
MELPHALAN (L-sarcolysin) 148-82-3 3617 M f swi ipj 26w79 1336m 0 .106mg .212mg Skipper;srfr;1976/Weisburger;canc;1977/Prejean pers.comm. lun mix e .165mg * P<.007 + 61.7ug 4.11mg 20/154 6/15 3/8 mgl ade e .617mg * P<.004 .152mg 10.1mg 0/154 1/15 1/8 --- lys e .702mg * P<.06 .154mg n.s.s. 3/154 0/15 2/8 adr fbs e 1.26mg * P<.03 .204mg n.s.s. 0/154 0/15 1/8 liv lys e no dre P=1. 97.5ug n.s.s. 1/154 0/15 0/8 tba mix e 51.0ug * P<.0005 23.3ug .167mg 42/154 10/15 7/8 tba mal e .104mg * P<.002 43.4ug .617mg 29/154 7/15 5/8 tba ben e .365mg * P<.08 .100mg n.s.s. 13/154 3/15 2/8 3618 M m swi ipj 26w77 1336m 0 .108mg lun mix e .137mg P<.005 + 54.6ug 1.57mg 9/101 9/28 --- lys e .302mg P<.02 + 94.4ug n.s.s. 2/101 4/28 liv mix e no dre P=1. .341mg n.s.s. 2/101 0/28 tba mix e 91.4ug P<.02 36.2ug n.s.s. 28/101 15/28 tba mal e .115mg P<.02 44.9ug n.s.s. 19/101 12/28 tba ben e 2.02mg P<.8 .140mg n.s.s. 9/101 3/28 3619 P b cym gav 16y18 2003 : 0 63.0ug Adamson;ossc,129-156;1982/Thorgeirsson 1994/Dalgard 1997/ Thorgeirsson&Seiber pers.comm. kid rca w .100mg P<.04 24.1ug n.s.s. 0/12 2/7 pnm ngs w .207mg P<.03 50.8ug n.s.s. 0/33 2/12 ute mix w 86.0ug P<.2 20.5ug n.s.s. 1/15 3/10 ute ena w .170mg P<.2 27.6ug n.s.s. 0/11 1/5 ute ley w .172mg P<.3 30.1ug n.s.s. 1/15 2/10 ski pam w .245mg P<.2 39.9ug n.s.s. 0/12 1/7 pal sqc w .358mg P<.2 58.3ug n.s.s. 0/13 1/10 pro car w .358mg P<.2 58.3ug n.s.s. 0/13 1/10 scl ecc w .358mg P<.2 58.3ug n.s.s. 0/13 1/10 tba mix Ww 40.3ug P<.005 15.7ug .389mg 2/33 8/12 tba mal Ww 70.1ug P<.02 + 23.2ug n.s.s. 1/33 5/12 tba ben w .157mg P<.3 30.3ug n.s.s. 2/20 3/10 3620 P b rhe gav 16y19 2003 : 0 64.0ug ute ley Ww 32.2ug P<.02 4.56ug n.s.s. 1/29 2/5 lun ade w .290mg P<.08 47.2ug n.s.s. 0/31 1/8 tba ben Ww 84.9ug P<.1 15.1ug n.s.s. 6/108 3/8 3621 R f cdr ipj 26w78 1336n 0 .129mg .304mg Skipper;srfr;1976/Weisburger;canc;1977/Prejean pers.comm. per sar e .135mg * P<.0005 + 63.2ug .371mg 0/182 8/16 1/6 lun a/a e 1.44mg * P<.02 .234mg n.s.s. 0/182 0/16 1/6 pan adc e 1.44mg * P<.02 .234mg n.s.s. 0/182 0/16 1/6 --- lys e 1.54mg * P<.09 .236mg n.s.s. 1/182 0/16 1/6 liv tum e no dre P=1. .112mg n.s.s. 0/182 0/16 0/6 tba mal e 78.1ug * P<.0005 35.2ug .310mg 44/182 13/16 3/6 tba mix e .106mg * P<.07 33.1ug n.s.s. 103/182 14/16 4/6 tba ben e no dre P=1. .319mg n.s.s. 59/182 1/16 1/6 3622 R m cdr ipj 26w67 1336n 0 .149mg per mix e 71.9ug P<.0005 + 32.0ug .212mg 0/177 8/18 --- lys e .359mg P<.003 88.1ug 4.84mg 0/177 2/18 liv tum e no dre P=1. .229mg n.s.s. 0/177 0/18 tba mix e 23.6ug P<.0005 9.76ug 77.1ug 59/177 16/18 tba mal e 47.0ug P<.0005 20.7ug .171mg 32/177 12/18 tba ben e .493mg P<.5 74.1ug n.s.s. 27/177 4/18
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.