|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|no positive||no positive||kid||no positive||no positive||1.45m|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
MERCURYMETHYL CHLORIDE (methylmercuric chloride) 115-09-3 3651 M f b6c eat 24m24 1961 0 52.0ug .260mg 1.30mg Mitsumori;faat,14,179-190;1990 kid rca er 65.8mg * P<.2 10.7mg n.s.s. 0/60 0/60 0/60 1/60 3652 M m b6c eat 24m24 1961 0 48.0ug .240mg 1.20mg kid mix ers 3.19mg * P<.0005 + 1.81mg 6.42mg 0/60 0/60 1/60 16/60 kid rcc ers 4.28mg * P<.0005 2.26mg 9.65mg 0/60 0/60 0/60 13/60 kid rca ers 9.83mg * P<.002 4.01mg 45.6mg 0/60 0/60 1/60 5/60 3653 M f cd1 wat 33m35 1395 0 .200mg .253mg Schroeder;jnut,105,452-458;1975 lun tum esv no dre P=1. - 3.28mg n.s.s. 9/47 3/31 3/40 tba mix esv 2.13mg \ P<.5 - .446mg n.s.s. 14/47 12/31 (4/40) tba mal esv no dre P=1. - 4.64mg n.s.s. 4/47 2/31 0/40 3654 M m cd1 wat 31m37 1395 0 .167mg .208mg lun tum esv no dre P=1. - 1.57mg n.s.s. 5/38 4/25 3/32 tba mix esv 5.63mg * P<.8 - .727mg n.s.s. 11/38 9/25 10/32 tba mal esv 9.64mg * P<.6 - 1.53mg n.s.s. 2/38 3/25 2/32 3655 M f icm eat 52w52 2035m 0 52.0ug .260mg 1.30mg Hirano;jjvs,48,127-135;1986/pers.comm. kid tum k no dre P=1. - 13.0ug n.s.s. 0/6 0/6 0/6 0/6 3656 M f icm eat 78w78 2035n 0 52.0ug .260mg 1.30mg kid tum k no dre P=1. - 29.2ug n.s.s. 0/6 0/6 0/6 0/6 3657 M f icm eat 24m24 2035o 0 52.0ug .260mg 1.30mg kid tum no dre P=1. - .363mg n.s.s. 0/42 0/42 0/42 0/42 3658 M f icm eat 80w80 2041 0 1.30mg Hirano;jjvs,50,886-893;1988 lun adc e 11.6mg P<.6 - 1.99mg n.s.s. 5/50 7/50 liv hem e 26.1mg P<.3 - 4.25mg n.s.s. 0/50 1/50 liv hpa e no dre P=1. - 7.93mg n.s.s. 5/50 0/50 liv hpc e no dre P=1. - 7.93mg n.s.s. 1/50 0/50 kid ade e no dre P=1. - 7.93mg n.s.s. 1/50 0/50 lun ade e no dre P=1. - 5.70mg n.s.s. 3/50 1/50 3659 M m icm eat 52w52 2035m 0 48.0ug .240mg 1.20mg Hirano;jjvs,48,127-135;1986/pers.comm. kid tum k no dre P=1. 12.0ug n.s.s. 0/6 0/6 0/6 0/6 3660 M m icm eat 78w78 2035n 0 48.0ug .240mg 1.20mg kid mix k .896mg * P<.006 + .264mg 10.9mg 0/6 0/6 0/6 3/6 kid adc k 3.20mg * P<.2 .520mg n.s.s. 0/6 0/6 0/6 1/6 3661 M m icm eat 24m24 2035o 0 48.0ug .240mg 1.20mg kid mix ae 1.69mg * P<.0005 + .802mg 4.78mg 1/26 0/19 0/23 10/20 kid adc ae 1.88mg * P<.0005 .876mg 5.14mg 0/26 0/19 0/23 9/20 3662 M m icm eat 80w80 2041 0 1.20mg Hirano;jjvs,50,886-893;1988 kid mix e 1.36mg P<.0005 + .746mg 2.89mg 0/50 15/50 kid adc e 1.48mg P<.0005 .795mg 3.23mg 0/50 14/50 lun adc e 5.10mg P<.3 1.37mg n.s.s. 6/50 10/50 kid ade e 24.1mg P<.3 3.92mg n.s.s. 0/50 1/50 liv hpa e no dre P=1. 3.33mg n.s.s. 12/50 6/50 liv hpb e no dre P=1. 7.32mg n.s.s. 2/50 0/50 liv hpc e no dre P=1. 3.45mg n.s.s. 7/50 4/50 lun ade e no dre P=1. 2.48mg n.s.s. 7/50 6/50 3663 R f sda eat 52w52 2541m 0 20.0ug .100mg .500mg Mitsumori;jjvs,46,549-557;1984/pers.comm. liv tum k no dre P=1. - 4.99ug n.s.s. 0/6 0/6 0/6 0/6 3664 R f sda eat 78w78 2541n 0 20.0ug .100mg .500mg liv tum k no dre P=1. - 11.2ug n.s.s. 0/6 0/6 0/6 0/6 3665 R f sda eat 30m30 2541o 0 20.0ug .100mg .500mg kid ade 15.7mg * P<.2 - 2.55mg n.s.s. 0/24 0/24 0/24 1/24 liv tum no dre P=1. - .125mg n.s.s. 0/24 0/24 0/24 0/24 3666 R m sda eat 52w52 2541m 0 16.0ug 80.0ug .400mg liv tum k no dre P=1. - 3.99ug n.s.s. 0/6 0/6 0/6 0/6 3667 R m sda eat 78w78 2541n 0 16.0ug 80.0ug .400mg liv tum k no dre P=1. - 8.97ug n.s.s. 0/6 0/6 0/6 0/6 3668 R m sda eat 30m30 2541o 0 16.0ug 80.0ug .400mg liv tum no dre P=1. - 99.7ug n.s.s. 0/24 0/24 0/24 0/24 3669 R f wis eat 24m24 2303 0 5.00ug 25.0ug .125mg Verschuuren;txcy,6,107-123;1976/1974/pers.comm. liv tum eg no dre P=1. - 20.1ug n.s.s. 0/25 0/24 0/25 0/25 3670 R m wis eat 24m24 2303 0 4.00ug 20.0ug .100mg liv tum e no dre P=1. - 15.9ug n.s.s. 0/23 0/25 0/20 0/23
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.