|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|lun nrv sto||no test||sto vsc||no test||0.0927||1.23|
|Monkey Target Sites||TD50
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
N-NITROSO-N-METHYLUREA 684-93-5 4449 M m c3h wat 30w54 2182 0 2.78mg 5.56mg 11.1mg Tatematsu;gann,84,1258-1264;1993/pers.comm. lun ade e .794mg Z P<.003 .380mg 3.14mg 0/10 10/21 (6/21 4/22) spl hms e 1.23mg * P<.0005 + .814mg 3.95mg 0/10 8/21 18/21 13/22 stg adc e 6.19mg * P<.004 + 3.10mg 36.2mg 0/10 1/21 3/21 7/22 liv nnd e 2.53mg Z P<.5 .538mg n.s.s. 3/10 9/21 (2/21 1/22) liv hpc e no dre P=1. 16.7mg n.s.s. 1/10 2/21 0/21 0/22 4450 P b cym eat 18y22 2004 : 0 6.32mg Adamson;ossc,129-156;1982/Thorgeirsson 1994/Dalgard 1997/ Thorgeirsson&Seiber pers.comm. ugi sqc jw 4.52mg P<.0005 + 1.22mg 18.6mg 0/63 6/16 eso mix jw 7.71mg P<.0005 + 2.95mg 27.9mg 0/63 6/16 eso sqc jw 10.5mg P<.002 + 3.75mg 46.0mg 0/63 5/16 orc mix jw 2.65mg P<.04 .652mg n.s.s. 0/4 2/2 phr sqc jw 82.2mg P<.08 13.4mg n.s.s. 0/63 1/16 pls sqc jw 7.95mg P<.2 1.29mg n.s.s. 0/4 1/2 ton sqp jw 7.95mg P<.2 1.29mg n.s.s. 0/4 1/2 sku rhb jw 23.9mg P<.2 3.88mg n.s.s. 0/10 1/5 eso sqp jw 29.2mg P<.2 4.75mg n.s.s. 0/12 1/6 col lei jw 34.5mg P<.2 5.61mg n.s.s. 0/14 1/7 hea rhm jw 66.3mg P<.2 10.8mg n.s.s. 0/26 1/13 sto adc jw 66.3mg P<.2 10.8mg n.s.s. 0/26 1/13 tba mix jw 2.64mg P<.005 .839mg 35.0mg 4/63 9/16 tba mal jw 4.00mg P<.02 1.26mg n.s.s. 3/63 7/16 tba ben jw 19.1mg P<.5 2.14mg n.s.s. 2/20 2/8 4451 P b rhe eat 18y22 2004 : 0 7.80mg ugi sqc jw 7.18mg P<.0005 + 3.23mg 21.0mg 1/72 9/16 eso sqc jw 8.20mg P<.0005 + 3.58mg 22.4mg 0/72 8/16 orc mix jw 15.7mg P<.003 4.90mg 143.mg 1/72 4/16 phr sqc jw 44.2mg P<.008 10.8mg 1.52gm 0/72 2/15 epg sqc jw 42.8mg P<.06 6.98mg n.s.s. 0/37 1/7 sto adc jw 42.8mg P<.06 6.98mg n.s.s. 0/37 1/7 gnv sqc jw 62.6mg P<.07 10.2mg n.s.s. 0/47 1/10 lar sqc jw 95.6mg P<.07 15.6mg n.s.s. 0/72 1/15 chp sqc jw 95.6mg P<.07 15.6mg n.s.s. 0/72 1/15 pls sqc jw 102.mg P<.07 16.6mg n.s.s. 0/72 1/16 ton sqc jw 72.9mg P<.3 8.84mg n.s.s. 1/72 1/16 tba mal Wjw 6.75mg P<.0005 2.79mg 26.2mg 5/74 9/16 4452 R m f34 gav 6m24 1915 0 .312mg Lijinsky;txih,5,925-935;1989 for tum 92.7ug P<.0005 + 44.1ug .203mg 0/12 18/20 lun mix .357mg P<.002 + .165mg 1.33mg 0/12 9/20 ner mix 2.03mg P<.2 + .498mg n.s.s. 0/12 2/20 liv tum 11.6mg P<.9 .574mg n.s.s. 1/12 2/20
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.