|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|no positive||no positive||liv||liv thy||no positive||35.8m|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
OXAZEPAM 604-75-1 4735 M f b6c eat 23m24 TR443 : 0 16.2mg 325.mg 650.mg liv MXA a 19.8mg Z P<.0005 c 12.7mg 32.6mg 28/50 36/50 50/50 47/50 liv:hpa,hpb,hpc. MXB MXB a 19.8mg Z P<.0005 12.7mg 32.6mg 28/50 36/50 50/50 47/50 liv:hpa,hpb,hpc; thy:fca. M liv hpa a 27.2mg Z P<.0005 c 16.8mg 47.7mg 25/50 35/50 35/50 36/50 liv hpc a 47.2mg Z P<.0005 c 30.0mg 76.0mg 9/50 5/50 49/50 44/50 thy fca a 160.mg Z P<.0005 p 68.3mg 573.mg 0/50 4/50 5/50 6/50 liv hpb a 476.mg Z P<.0005 c 221.mg 1.07gm 0/50 1/50 8/50 8/50 TBA MXB a 20.2mg Z P<.0005 12.9mg 33.4mg 37/50 43/50 50/50 47/50 liv MXB a 19.8mg Z P<.0005 12.7mg 32.6mg 28/50 36/50 50/50 47/50 liv:hpa,hpb,hpc. lun MXB a 811.mg * P<.2 121.mg n.s.s. 5/50 4/50 1/50 1/50 lun:a/a,a/c. 4736 M f sww eat 57w57 TR443 : 0 325.mg 650.mg liv MXA s 64.8mg * P<.0005 c 46.4mg 94.0mg 1/60 23/60 47/60 liv:hpa,hpc. liv hpa s 65.8mg * P<.0005 c 47.3mg 94.1mg 0/60 22/60 47/60 liv hpc s 360.mg / P<.0005 c 176.mg 1.06gm 1/60 1/60 11/60 TBA MXB s 79.9mg * P<.0005 50.9mg 155.mg 24/60 37/60 49/60 liv MXB s 64.8mg * P<.0005 46.4mg 94.0mg 1/60 23/60 47/60 liv:hpa,hpb,hpc. lun MXB s 1.48gm * P<.5 273.mg n.s.s. 11/60 6/60 7/60 lun:a/a,a/c. 4737 M m b6c eat 23m24 TR443 : 0 15.0mg 300.mg 600.mg liv MXA a 59.0mg Z P<.0005 c 40.5mg 89.4mg 23/50 19/50 50/50 50/50 liv:hpa,hpb,hpc. liv MXA a 68.3mg Z P<.0005 c 47.6mg 101.mg 9/50 6/50 47/50 50/50 liv:hpb,hpc. liv hpc a 73.5mg Z P<.0005 c 51.1mg 109.mg 9/50 5/50 45/50 50/50 liv hpa a 93.7mg Z P<.0005 c 60.0mg 157.mg 17/50 18/50 34/50 32/50 liv hpb a 205.mg * P<.0005 c 126.mg 347.mg 0/50 2/50 21/50 13/50 TBA MXB a 54.0mg Z P<.0005 37.0mg 83.5mg 37/50 35/50 50/50 50/50 liv MXB a 59.0mg Z P<.0005 40.5mg 89.4mg 23/50 19/50 50/50 50/50 liv:hpa,hpb,hpc. lun MXB a no dre P=1. 407.mg n.s.s. 13/50 18/50 5/50 1/50 lun:a/a,a/c. 4738 M m sww eat 57w57 TR443 : 0 300.mg 600.mg liv MXA s 34.6mg * P<.0005 c 24.7mg 49.6mg 1/60 35/60 52/60 liv:hpa,hpc. liv hpa s 35.0mg * P<.0005 c 25.0mg 50.6mg 1/60 35/60 50/60 liv hpc s 139.mg / P<.0005 c 80.4mg 257.mg 0/60 5/60 19/60 TBA MXB s 47.0mg * P<.0005 30.3mg 83.5mg 26/60 42/60 54/60 liv MXB s 34.6mg * P<.0005 24.7mg 49.6mg 1/60 35/60 52/60 liv:hpa,hpb,hpc. lun MXB s 755.mg * P<.4 163.mg n.s.s. 14/60 9/60 7/60 lun:a/a,a/c. 4739 R f f34 eat 24m24 TR468 : 0 31.3mg 125.mg 250.mg --- mnl # 114.mg Z P<.002 - 57.8mg 575.mg 14/50 19/50 29/50 (18/50) S TBA MXB 170.mg Z P<.3 46.2mg n.s.s. 49/50 49/50 45/50 (38/50) liv MXB no dre P=1. n.s.s. n.s.s. 0/50 0/50 0/50 0/50 liv:hpa,hpb,hpc. 4740 R f f34 eat 6m24 TR468a : 0 124.mg TBA MXB no dre P=1. - 75.0mg n.s.s. 49/50 43/50 liv MXB no dre P=1. n.s.s. n.s.s. 0/50 0/50 liv:hpa,hpb,hpc. 4741 R m f34 eat 23m23 TR468 : 0 25.0mg 100.mg 200.mg tes MXA # 27.4mg * P<.0005 - 16.6mg 56.3mg 45/50 48/50 49/50 47/50 tes:iab,ica. S --- mnl 79.1mg * P<.005 36.1mg 926.mg 27/50 36/50 33/50 19/50 S thy MXA 336.mg * P<.02 116.mg n.s.s. 4/50 3/50 4/50 6/50 thy:fca,fcc. S kid rua 500.mg * P<.05 142.mg n.s.s. 1/50 0/50 3/50 1/50 S TBA MXB 50.4mg * P<.002 25.5mg 225.mg 47/50 45/50 44/50 32/50 liv MXB C 1.79gm * P<.2 293.mg n.s.s. 2/50 0/50 0/50 3/50 liv:hpa,hpb,hpc. 4742 R m f34 eat 23m23 TR468 with step 0 25.0mg 100.mg 200.mg kid rua 1.01gm * P<.03 e 434.mg n.s.s. 2/50 1/50 7/50 6/50 4743 R m f34 eat 6m24 TR468a : 0 101.mg tes MXA # 16.9mg P<.0005 - 8.32mg 52.9mg 45/50 48/50 tes:iab,ica. S --- mnl 31.0mg P<.0005 14.3mg 115.mg 27/50 34/50 S kid rua no dre P=1. 62.0mg n.s.s. 1/50 0/50 TBA MXB 27.5mg P<.004 11.8mg 237.mg 47/50 42/50 liv MXB C no dre P=1. 91.6mg n.s.s. 2/50 1/50 liv:hpa,hpb,hpc. 4744 R m f34 eat 6m24 TR468a with step 0 101.mg kid rua 779.mg P<.2 e 241.mg n.s.s. 2/50 6/50
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.