|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|no positive||no positive||liv thy||liv||no positive||26.1m|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
PRIMIDONE 125-33-7 5249 M f b6c eat 23m24 TR476 : 0 37.9mg 75.8mg 164.mg liv hpa 27.7mg Z P<.002 c 14.6mg 115.mg 15/50 42/50 (45/50 47/50) liv MXA 28.9mg Z P<.002 c 14.9mg 142.mg 16/50 42/50 (45/50 50/50) liv:hpa,hpc. liv MXA 42.8mg Z P<.0005 c 24.2mg 157.mg 16/50 42/50 46/50 (50/50) liv:hpa,hpb,hpc. liv hpc 97.3mg * P<.0005 c 67.2mg 167.mg 3/50 11/50 19/50 38/50 liv MXA 98.7mg * P<.0005 c 67.3mg 175.mg 4/50 12/50 20/50 39/50 liv:hpb,hpc. liv hpb 1.39gm * P<.3 399.mg n.s.s. 1/50 4/50 4/50 4/50 TBA MXB 163.mg * P<.08 63.2mg n.s.s. 34/50 47/50 47/50 50/50 liv MXB 42.8mg Z P<.0005 24.2mg 157.mg 16/50 42/50 46/50 (50/50) liv:hpa,hpb,hpc. lun MXB no dre P=1. 844.mg n.s.s. 7/50 5/50 4/50 3/50 lun:a/a,a/c. 5250 M m b6c eat 23m24 TR476 : 0 35.0mg 70.1mg 152.mg liv MXA 24.7mg Z P<.0005 c 13.6mg 76.5mg 12/50 39/50 (40/50 39/50) liv:hpb,hpc. liv hpb 52.5mg Z P<.0005 35.9mg 80.7mg 0/50 17/50 26/50 (7/50) S liv hpc 55.0mg * P<.0005 34.3mg 119.mg 12/50 31/50 35/50 38/50 S liv MXA 60.2mg * P<.002 c 32.2mg 264.mg 31/50 49/50 49/50 46/50 liv:hpa,hpb,hpc. MXB MXB 60.2mg * P<.002 32.2mg 264.mg 31/50 49/50 49/50 46/50 liv:hpa,hpb,hpc; thy:fca. M liv MXA 60.4mg * P<.002 c 32.4mg 261.mg 31/50 48/50 47/50 46/50 liv:hpa,hpc. thy fca 349.mg * P<.002 p 179.mg 1.43gm 0/50 3/50 3/50 6/50 liv hpa 46.8mg Z P<.02 22.8mg 34.3gm 22/50 41/50 39/50 (32/50) S --- hcs 1.15gm Z P<.03 391.mg n.s.s. 1/50 0/50 0/50 5/50 S TBA MXB 77.6mg * P<.01 36.9mg 3.75gm 40/50 50/50 50/50 47/50 liv MXB 60.2mg * P<.002 32.2mg 264.mg 31/50 49/50 49/50 46/50 liv:hpa,hpb,hpc. lun MXB 1.76gm * P<.7 229.mg n.s.s. 11/50 9/50 6/50 9/50 lun:a/a,a/c. 5251 R f f34 eat 23m24 TR476 : 0 29.3mg 63.6mg 122.mg TBA MXB no dre P=1. - 104.mg n.s.s. 47/50 44/50 41/50 46/50 liv MXB 4.05gm * P<.6 631.mg n.s.s. 0/50 1/50 0/50 1/50 liv:hpa,hpb,hpc. 5252 R m f34 eat 23m24 TR476 : 0 23.5mg 50.8mg 100.mg tes MXA as 8.15mg Z P<.0005 4.97mg 15.2mg 41/50 44/50 42/50 43/50 tes:iab,ica. S amd MXA as 20.8mg * P<.0005 10.4mg 75.6mg 23/50 28/50 24/50 12/50 amd:pbb,phm,pob. S amd MXA as 20.8mg * P<.0005 10.4mg 75.6mg 23/50 28/50 24/50 12/50 amd:pbb,pob. S thy MXA as 80.2mg * P<.003 e 29.4mg 557.mg 2/50 4/50 7/50 4/50 thy:fca,fcc. thy fca as 174.mg * P<.005 63.2mg 2.02gm 1/50 1/50 6/50 3/50 S kid MXA as 522.mg * P<.3 69.1mg n.s.s. 2/50 1/50 1/50 2/50 kid:rua,ruc. kid rua as 1.28gm * P<.7 80.1mg n.s.s. 2/50 1/50 1/50 1/50 TBA MXB as 15.4mg * P<.0005 7.98mg 50.2mg 49/50 45/50 46/50 26/50 liv MXB as 138.mg Z P<.09 32.3mg n.s.s. 1/50 1/50 1/50 1/50 liv:hpa,hpb,hpc. 5253 R m f34 eat 23m24 TR476 with step 0 23.5mg 50.8mg 100.mg kid MXA a 967.mg * P<.2 e 295.mg n.s.s. 4/50 2/50 4/50 7/50 kid:rua,ruc. kid rua a 1.29gm * P<.4 325.mg n.s.s. 4/50 2/50 4/50 6/50
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.