|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
PYRIDINE 110-86-1 5364 M f b6c wat 24m24 TR470 : 0 25.0mg 50.0mg 100.mg liv MXA 27.2mg Z P<.0005 c 15.9mg 73.2mg 13/50 23/50 36/50 (43/50) liv:hpb,hpc. liv hpc 41.6mg * P<.0005 c 25.0mg 103.mg 13/50 23/50 33/50 41/50 liv hpb 132.mg * P<.0005 c 79.8mg 287.mg 1/50 2/50 9/50 16/50 liv hpa 41.9mg Z P<.08 16.5mg n.s.s. 37/50 39/50 43/50 (34/50) --- MXA 690.mg * P<.02 260.mg n.s.s. 0/50 0/50 2/50 3/50 ---:hem,hes. S --- hem 868.mg * P<.02 297.mg n.s.s. 0/50 0/50 1/50 3/50 S TBA MXB 338.mg * P<.7 44.9mg n.s.s. 47/50 45/50 45/50 45/50 liv MXB 150.mg * P<.4 38.6mg n.s.s. 41/50 42/50 45/50 44/50 liv:hpa,hpb,hpc. lun MXB 1.99gm * P<.7 250.mg n.s.s. 4/50 4/50 2/50 5/50 lun:a/a,a/c. 5365 M m b6c wat 24m24 TR470 : 0 41.7mg 83.3mg 167.mg liv MXA 22.1mg Z P<.0005 c 12.0mg 67.3mg 17/50 42/50 (45/50 42/50) liv:hpb,hpc. liv hpc 28.6mg Z P<.0005 c 14.8mg 116.mg 15/50 35/50 (41/50 40/50) liv hpb 68.1mg Z P<.0005 c 42.9mg 153.mg 2/50 18/50 22/50 (15/50) liv hpa 488.mg Z P<.6 91.0mg n.s.s. 29/50 40/50 34/50 39/50 TBA MXB 25.7gm * P<1. 94.1mg n.s.s. 43/50 49/50 48/50 47/50 liv MXB 496.mg * P<.7 79.3mg n.s.s. 38/50 47/50 46/50 47/50 liv:hpa,hpb,hpc. lun MXB no dre P=1. 476.mg n.s.s. 13/50 7/50 9/50 8/50 lun:a/a,a/c. 5366 R f f34 wat 24m24 TR470 : 0 5.71mg 11.4mg 22.9mg --- mnl 31.2mg * P<.008 e 15.3mg 795.mg 12/50 16/50 22/50 23/50 TBA MXB 32.9mg * P<.3 9.85mg n.s.s. 45/50 42/50 45/50 44/50 liv MXB no dre P=1. 161.mg n.s.s. 1/50 0/50 1/50 0/50 liv:hpa,hpb,hpc. 5367 R m f34 wat 24m24 TR470 : 0 5.00mg 10.0mg 20.0mg kid rua 73.7mg * P<.009 p 30.4mg 2.01gm 1/50 0/50 2/50 6/50 kid MXA 67.3mg * P<.02 p 28.1mg n.s.s. 1/50 1/50 2/50 6/50 kid:rua,ruc. TBA MXB 31.0mg * P<.4 7.65mg n.s.s. 46/50 45/50 46/50 43/50 liv MXB 160.mg * P<.2 44.1mg n.s.s. 1/50 1/50 1/50 3/50 liv:hpa,hpb,hpc. 5368 R m f34 wat 24m24 TR470 with step 0 5.00mg 9.99mg 20.0mg kid MXA 74.6mg * P<.008 p 36.2mg 1.92gm 2/50 4/50 6/50 10/50 kid:rua,ruc. kid rua 75.6mg * P<.006 p 37.1mg 920.mg 2/50 3/50 6/50 10/50 5369 R m wis wat 24m24 TR470a : 0 5.00mg 10.0mg 20.0mg tes MXA 22.4mg * P<.003 e 10.2mg 157.mg 5/50 6/50 4/50 12/50 tes:iab,ica. thy MXA 38.4mg Z P<.005 13.9mg 318.mg 0/50 0/50 5/50 (0/50) thy:fab,fca. S TBA MXB 7.14mg * P<.005 3.50mg 64.7mg 43/50 38/50 32/50 39/50 liv MXB no dre P=1. 55.8mg n.s.s. 2/50 0/50 1/50 0/50 liv:hpa,hpb,hpc.
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.