|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|adr nas||mgl nas sto||nas||nas||74.4m,v||912m|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
1,2-PROPYLENE OXIDE (1,2-epoxypropane) 75-56-9 5334 M f b6c inh 24m24 TR267 : 0 148.mg 296.mg --- MXA 863.mg / P<.003 360.mg 5.43gm 1/50 1/50 7/50 ---:hem,hes. S nas MXA 1.21gm / P<.002 c 451.mg 4.63gm 0/50 0/50 5/50 nas:hem,hes. mgl MXA 1.26gm * P<.01 475.mg 80.3gm 0/50 3/50 3/50 mgl:adc,adq. S lun a/a 588.mg * P<.02 243.mg n.s.s. 4/50 7/50 6/50 S --- hes 1.61gm * P<.02 522.mg n.s.s. 0/50 1/50 3/50 S --- hem 1.81gm / P<.05 554.mg n.s.s. 1/50 0/50 4/50 S nas hem 2.02gm * P<.02 606.mg n.s.s. 0/50 0/50 3/50 S mgl adq 2.77gm * P<.03 732.mg n.s.s. 0/50 0/50 3/50 S TBA MXB 226.mg * P<.01 107.mg 15.0gm 28/50 35/50 23/50 liv MXB 979.mg * P<.2 320.mg n.s.s. 3/50 7/50 3/50 liv:hpa,hpc,nnd. lun MXB 588.mg * P<.02 243.mg n.s.s. 4/50 7/50 6/50 lun:a/a,a/c. 5335 M m b6c inh 24m24 TR267 : 0 123.mg 247.mg nas MXA 732.mg / P<.0005 c 355.mg 1.95gm 0/50 0/50 10/50 nas:hem,hes. --- MXA 753.mg * P<.006 342.mg 8.20gm 2/50 2/50 10/50 ---:hem,hes. S nas hem 1.47gm * P<.005 558.mg 12.1gm 0/50 0/50 5/50 S nas hes 1.61gm * P<.006 604.mg 15.1gm 0/50 0/50 5/50 S TBA MXB 722.mg * P<.4 173.mg n.s.s. 29/50 31/50 27/50 liv MXB no dre P=1. 425.mg n.s.s. 14/50 16/50 9/50 liv:hpa,hpc,nnd. lun MXB no dre P=1. 469.mg n.s.s. 15/50 14/50 8/50 lun:a/a,a/c. 5336 R f f34 inh 24m24 TR267 : 0 35.2mg 70.4mg MXA MXA 156.mg * P<.04 71.3mg n.s.s. 3/50 12/50 10/50 cvu:esp; ute:esp,ess. S nas ppa 732.mg * P<.04 p 221.mg n.s.s. 0/50 0/50 3/50 TBA MXB 124.mg * P<.4 32.8mg n.s.s. 38/50 46/50 44/50 liv MXB no dre P=1. 1.01gm n.s.s. 1/50 0/50 0/50 liv:hpa,hpc,nnd. 5337 R m f34 inh 24m24 TR267 : 0 24.7mg 49.3mg nas ppa 826.mg * P<.1 p 202.mg n.s.s. 0/50 0/50 2/50 TBA MXB 220.mg * P<.8 27.8mg n.s.s. 40/50 41/50 45/50 liv MXB 528.mg * P<.4 133.mg n.s.s. 1/50 2/50 3/50 liv:hpa,hpc,nnd. 5338 R m f34 inh 23m24 1624 () pool 0 14.2mg 42.4mg Lynch;txap,76,69-84;1984 adr phe eis 35.1mg \ P<.002 + 18.4mg 144.mg 8/78 25/78 (22/80) liv hpc eis 2.96gm * P<.3 482.mg n.s.s. 0/78 0/78 1/76 liv nnd eis no dre P=1. 509.mg n.s.s. 2/78 1/78 1/76 5339 R f sda gav 25m35 1486 0 3.13mg 12.5mg Dunkelberg;bjca,46,924-933;1982 sto mix e 39.5mg * P<.0005 + 24.0mg 71.6mg 0/50 2/50 21/50 for sqc e 44.3mg * P<.0005 + 26.3mg 82.6mg 0/50 2/50 19/50 5340 R f wsr inh 29m29 1830 0 5.33mg 17.8mg 53.3mg Kuper;fctx,26,159-167;1988 mgl fba e 92.6mg * P<.003 + 46.7mg 602.mg 32/69 30/71 39/69 47/70 mgl adc e 813.mg * P<.2 235.mg n.s.s. 3/69 6/71 5/69 8/70 liv cho 2.46gm * P<.5 447.mg n.s.s. 2/69 1/71 2/69 3/70 res car e no dre P=1. 77.4mg n.s.s. 0/69 0/71 0/69 0/70 tba tum e 25.7mg * P<.0005 14.0mg 69.4mg 52/69 49/71 61/69 67/70 tba mal e 150.mg * P<.0005 81.1mg 510.mg 6/69 15/71 14/69 26/70 5341 R m wsr inh 29m29 1830 0 3.73mg 12.4mg 37.3mg res car eh 896.mg * P<.005 310.mg 7.93gm 0/70 0/69 0/71 4/70 liv nnd no dre P=1. 604.mg n.s.s. 0/70 0/69 1/71 0/70 liv clc no dre P=1. 630.mg n.s.s. 1/70 0/69 2/71 0/70 tba mal e 101.mg * P<.002 51.3mg 569.mg 19/70 17/69 22/71 34/70 tba tum e 79.3mg Z P<.02 35.9mg n.s.s. 49/70 28/69 34/71 53/70
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.