|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|no positive||no positive||adr liv||adr liv vsc||no positive||24m|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
2,3,4,5,6-PENTACHLOROPHENOL (Dowicide EC-7) 87-86-5 4829 M f b6c eat 24m24 TR349 : 0 12.8mg 25.6mg 76.9mg MXB MXB 28.7mg * P<.0005 19.4mg 47.8mg 1/35 6/50 9/50 42/50 ---:hes; amd:pbb,phm,pob; liv:hpa,hpc. C liv MXA 38.3mg * P<.0005 c 24.4mg 71.6mg 1/35 4/50 6/50 31/50 liv:hpa,hpc. amd MXA 38.8mg Z P<.0005 c 25.7mg 61.2mg 0/35 2/50 2/50 38/50 amd:pbb,phm,pob. amd MXA 40.3mg Z P<.0005 26.6mg 64.0mg 0/35 1/50 2/50 38/50 amd:pbb,pob. S liv hpa 40.6mg * P<.0005 25.8mg 75.3mg 1/35 3/50 6/50 30/50 S --- MXA 187.mg * P<.0005 93.8mg 646.mg 0/35 1/50 3/50 9/50 ---:hem,hes. S --- hes 200.mg * P<.002 c 97.8mg 878.mg 0/35 1/50 3/50 8/50 TBA MXB 86.1mg Z P<.2 29.6mg n.s.s. 24/35 29/50 25/50 46/50 liv MXB 38.3mg * P<.0005 24.4mg 71.6mg 1/35 4/50 6/50 31/50 liv:hpa,hpc,nnd. lun MXB 12.8gm * P<1. 221.mg n.s.s. 2/35 3/50 1/50 3/50 lun:a/a,a/c. 4830 M f b6c orl 76w76 1285 0 18.1mg Innes;ntis,1968/1969 lun ade evx 56.1mg P<.2 - 13.8mg n.s.s. 0/16 2/18 liv hpt evx no dre P=1. - 35.8mg n.s.s. 0/16 0/18 tba mix evx 26.3mg P<.02 - 9.04mg n.s.s. 0/16 4/18 4831 M m b6c eat 24m24 TR349 : 0 11.8mg 23.7mg 71.0mg amd MXA 17.4mg * P<.0005 12.4mg 25.6mg 0/35 4/50 21/50 44/50 amd:pbb,pob. S amd MXA 17.5mg * P<.0005 c 12.2mg 28.2mg 1/35 4/50 21/50 45/50 amd:pbb,phm,pmb,pob. MXB MXB 24.9mg Z P<.0005 13.9mg 72.0mg 7/35 21/50 27/50 45/50 amd:pbb,phm,pmb,pob; liv:hpa,hpc. C liv hpa 36.2mg * P<.0005 19.2mg 128.mg 5/35 13/50 17/50 32/50 S liv MXA 38.3mg Z P<.003 c 18.8mg 224.mg 6/35 19/50 21/50 34/50 liv:hpa,hpc. TBA MXB 57.8mg * P<.09 21.2mg n.s.s. 20/35 32/50 33/50 46/50 liv MXB 38.3mg Z P<.003 18.8mg 224.mg 6/35 19/50 21/50 34/50 liv:hpa,hpc,nnd. lun MXB 1.94gm * P<.9 143.mg n.s.s. 5/35 1/50 2/50 5/50 lun:a/a,a/c. 4832 M m b6c orl 76w76 1285 0 16.8mg Innes;ntis,1968/1969 liv hpt evx 108.mg P<.3 - 17.5mg n.s.s. 0/16 1/18 lun ade evx 108.mg P<.3 - 17.5mg n.s.s. 0/16 1/18 tba mix evx 33.7mg P<.05 - 10.2mg n.s.s. 0/16 3/18 4833 M f b6a orl 76w76 1285 0 18.1mg liv hpt evx no dre P=1. - 35.8mg n.s.s. 0/17 0/18 lun ade evx no dre P=1. - 35.8mg n.s.s. 1/17 0/18 tba mix evx no dre P=1. - 17.0mg n.s.s. 2/17 2/18 4834 M m b6a orl 76w76 1285 0 16.8mg liv mix evx 90.4mg P<.6 - 13.2mg n.s.s. 1/18 2/17 lun ade evx no dre P=1. - 20.7mg n.s.s. 2/18 1/17 tba mix evx 520.mg P<1. - 12.2mg n.s.s. 3/18 3/17 4835 R f sss eat 24m24 1401 0 1.00mg 3.00mg 10.0mg 30.0mg Schwetz;pcpl,301-309;1978 tba tum e no dre P=1. - 10.0mg n.s.s. 27/27 26/27 25/27 25/27 25/27 4836 R m sss eat 95w95 1401 0 1.00mg 3.00mg 10.0mg 30.0mg tba tum e no dre P=1. - 33.4mg n.s.s. 11/27 13/26 13/27 12/27 11/27
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.