|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|ezy lun||cli ezy lun mgl||no positive||liv ova||8.67m||45.8|
|Hamster Target Sites||TD50
|no test||no positive||no positive|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
5-NITROACENAPHTHENE 602-87-9 4304 H f syg eat 26w71 1091 0 382.mg Takemura;bjca,30,481-483;1974 bil cho 354.mg P<.003 152.mg 1.66gm 0/20 7/24 4305 M f b6c eat 78w96 TR118 : 0 53.3mg 127.mg MXB MXB ev 45.3mg * P<.0005 29.3mg 87.4mg 2/50 23/50 19/50 liv:hpc; ova:gct,lut,tua. C liv hpc ev 45.8mg * P<.0005 c 29.5mg 90.3mg 2/50 23/50 18/50 ova MXA ev 217.mg * P<.0005 c 108.mg 623.mg 0/50 4/50 7/50 ova:gct,lut,tua. ova tua ev 395.mg * P<.005 c 161.mg 3.08gm 0/50 2/50 4/50 TBA MXB ev 90.4mg * P<.02 40.3mg n.s.s. 19/50 29/50 21/50 liv MXB ev 45.8mg * P<.0005 29.5mg 90.3mg 2/50 23/50 18/50 liv:hpa,hpc,nnd. lun MXB ev 1.32gm * P<.5 232.mg n.s.s. 2/50 3/50 2/50 lun:a/a,a/c. 4306 M m b6c eat 78w95 TR118 : 0 58.8mg 140.mg TBA MXB es no dre P=1. - 74.6mg n.s.s. 23/50 15/50 1/50 liv MXB es no dre P=1. 132.mg n.s.s. 12/50 7/50 0/50 liv:hpa,hpc,nnd. lun MXB es no dre P=1. 152.mg n.s.s. 5/50 4/50 0/50 lun:a/a,a/c. 4307 R f f34 eat 18m23 TR118 : 0 43.0mg 87.0mg MXB MXB e 5.98mg / P<.0005 1.96mg 11.3mg 1/100 37/50 38/50 cli:can; eac:cas,cuc,sqc; lun:a/a,a/c; mgl:acn,pcn. C lun MXA e 9.63mg * P<.0005 c 2.18mg 44.5mg 1/100 8/50 3/50 lun:a/a,a/c. eac MXA e 14.9mg / P<.0005 c 7.28mg 24.8mg 0/100 27/50 35/50 eac:cas,cuc,sqc. eac cuc e 17.4mg * P<.0005 c 7.85mg 30.9mg 0/100 25/50 26/50 cli can e 52.2mg * P<.0005 c 18.7mg 143.mg 0/100 6/50 5/50 mgl MXA e 77.9mg * P<.0005 c 31.5mg 198.mg 0/100 6/50 5/50 mgl:acn,pcn. mgl acn e 81.7mg * P<.0005 c 32.1mg 220.mg 0/100 5/50 5/50 eac sqc e 90.5mg / P<.0005 c 29.9mg 230.mg 0/100 3/50 9/50 TBA MXB e 6.44mg / P<.0005 3.78mg 10.5mg 83/100 46/50 45/50 liv MXB e no dre P=1. n.s.s. n.s.s. 2/100 0/50 0/50 liv:hpa,hpc,nnd. 4308 R m f34 eat 17m23 TR118 : 0 34.4mg 62.4mg MXB MXB ae 6.45mg / P<.0005 1.67mg 17.7mg 1/99 25/50 21/50 eac:cuc,sqc; lun:a/a,a/c. C eac MXA ae 7.88mg * P<.0005 c 1.71mg 27.8mg 0/99 21/50 20/50 eac:cuc,sqc. eac cuc ae 8.92mg * P<.0005 c 1.75mg 45.1mg 0/99 14/50 18/50 lun MXA ae 29.9mg * P<.0005 c 9.96mg 93.8mg 1/99 7/50 3/50 lun:a/a,a/c. lun a/c ae 35.1mg * P<.0005 c 10.4mg 171.mg 1/99 5/50 0/50 thy MXA ae 37.7mg / P<.0005 10.6mg 210.mg 0/99 4/50 1/50 thy:fcc,pac. S kid MXA ae 42.9mg * P<.0005 13.5mg 204.mg 0/99 4/50 0/50 kid:tla,uac. S thy MXA ae 58.5mg * P<.0005 15.4mg 323.mg 0/99 4/50 0/50 thy:fca,ppa. S eac sqc ae 68.2mg * P<.0005 c 27.4mg 188.mg 0/99 7/50 2/50 TBA MXB ae 5.58mg / P<.0005 2.91mg 10.1mg 58/99 39/50 30/50 liv MXB ae 71.4mg * P<.08 5.92mg n.s.s. 4/99 1/50 0/50 liv:hpa,hpc,nnd.
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.