Rat Target Sites  Mouse Target Sites  TD_{50} (mg/kg/day)  
Male  Female  Male  Female  Rat  Mouse 
kid per thy  kid  kid  no positive  9.82^{m}  53.8 
Hamster Target Sites  TD_{50} (mg/kg/day) 

Male  Female  
kid  no test  533^{n} 
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, longterm animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD_{50}) and its statistical significance; shape of the doseresponse, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD_{50} estimation for a standard lifespan. See Methods for other details.
TD_{50} provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD_{50} values across chemicals that are rodent carcinogens is more than 100 millionfold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
BROMATE, POTASSIUM 7758012 828 H m syg wat 89w89 2318 0 15.0mg 30.0mg 60.0mg 240.mg Takamura;srtu,32,4346;1985 kid rct h 533.mg * P<.2 + 202.mg n.s.s. 0/20 0/20 1/20 4/20 2/20 liv nnd no dre P=1. 577.mg n.s.s. 0/20 0/20 0/20 1/20 0/20 tba mix no dre P=1. 196.mg n.s.s. 10/20 14/20 7/20 8/20 9/20 829 M f b6c wat 18m24 1789 0 75.0mg 150.mg Kurokawa;enhp,69,221235;1986 liv ade e 1.18gm * P<.05 480.mg n.s.s. 0/46 3/48 3/47 lun mix e 1.05gm * P<.2 369.mg n.s.s. 3/46 3/48 8/47 liv mix e 1.71gm * P<.4 449.mg n.s.s. 3/46 3/48 6/47 lun ade e 2.03gm * P<.3 549.mg n.s.s. 2/46 1/48 5/47 tba mix e 477.mg * P<.2 163.mg n.s.s. 15/46 16/48 22/47 830 M m b6c wat 52w53 2348m 0 13.3mg 66.7mg 133.mg DeAngelo;txpy,26,587594;1998/pers.comm. kid tum ek no dre P=1. 3.79mg n.s.s. 0/7 0/7 0/7 0/6 831 M m b6c wat 78w78 2348n 0 13.3mg 66.7mg 133.mg kid tum ek no dre P=1. 8.07mg n.s.s. 0/7 0/7 0/7 0/5 832 M m b6c wat 23m23 2348o : 0 13.3mg 66.7mg 133.mg kid mix 53.8mg Z P<.008 + 20.4mg 861.mg 0/40 5/38 (3/41 1/44) kid rcc 92.5mg Z P<.04 28.0mg n.s.s. 0/40 3/38 (1/41 0/44) 833 M f the eat 80w80 719 0 6.50mg 9.75mg Ginocchio;fctx,17,4147;1979 liv hem e 347.mg * P<.6  56.4mg n.s.s. 0/53 1/54 0/52 834 M m the eat 80w80 719 0 6.00mg 9.00mg liv tum e no dre P=1.  21.3mg n.s.s. 0/35 0/46 0/53 tba mal e no dre P=1.  63.9mg n.s.s. 1/35 1/46 0/53 835 R f f34 wat 26m26 1550 0 14.2mg 28.3mg Kurokawa;jnci,71,965972;1983 kid mix e 13.7mg * P<.0005 + 9.90mg 19.5mg 0/47 28/50 39/49 kid adc e 16.4mg * P<.0005 11.7mg 23.7mg 0/47 21/50 39/49 kid ade e 87.5mg * P<.0005 49.6mg 234.mg 0/47 8/50 9/49 thy mix e 97.6mg * P<.01 48.2mg 7.87gm 3/52 10/52 12/52 liv mix e no dre P=1. 220.mg n.s.s. 2/52 1/52 2/52 tba mix e 9.05mg * P<.003 3.96mg 62.6mg 44/52 48/52 52/52 836 R m f34 wat 26m26 1550 0 12.4mg 22.5mg kid mix ev 9.62mg * P<.0005 + 6.93mg 13.9mg 3/53 32/53 46/52 kid adc ev 12.6mg * P<.0005 9.00mg 18.6mg 3/53 24/53 44/52 per mso ev 25.3mg * P<.0005 + 16.1mg 49.8mg 6/53 17/52 28/46 kid ade ev 46.2mg \ P<.0005 22.5mg 124.mg 0/53 10/53 (5/52) liv mix ev 164.mg * P<.2 62.8mg n.s.s. 2/53 7/53 6/52 tba mix ev noTD50 P=1. n.s.s. n.s.s. 53/53 53/53 52/52 837 R m f34 wat 52w52 2348m 0 1.00mg 5.00mg 10.0mg 20.0mg DeAngelo;txpy,26,587594;1998/pers.comm. kid rca ek 16.7mg * P<.04 4.09mg n.s.s. 0/6 0/6 0/6 0/6 2/6 tnv mso ek 36.1mg * P<.5 5.88mg n.s.s. 0/6 0/6 0/6 1/6 0/6 838 R m f34 wat 77w77 2348n 0 1.00mg 5.00mg 10.0mg 20.0mg kid rca ek 15.3mg * P<.003 5.18mg 98.3mg 0/6 0/6 0/6 0/5 4/6 tnv mso ek 15.3mg * P<.003 5.18mg 98.3mg 0/6 0/6 0/6 0/5 4/6 thy mix ek 21.8mg * P<.01 6.53mg 1.32gm 0/6 0/6 0/6 0/5 3/6 thy fcc ek 34.8mg * P<.04 8.51mg n.s.s. 0/6 0/6 0/6 0/5 2/6 839 R m f34 wat 23m23 2348o : 0 1.00mg 5.00mg 10.0mg 20.0mg tnv mso as 11.1mg Z P<.0005 + 7.49mg 17.8mg 0/47 4/49 5/48 9/47 27/43 kid mix as 20.8mg Z P<.0005 + 11.8mg 45.6mg 1/45 1/41 6/45 3/38 12/31 thy mix as 22.2mg Z P<.0005 + 12.2mg 52.2mg 0/36 4/38 1/42 4/36 14/30 kid rca as 31.1mg Z P<.0005 15.7mg 87.6mg 1/45 1/41 4/45 2/38 9/31 thy fca as 35.2mg Z P<.0005 17.4mg 116.mg 0/36 2/38 1/42 2/36 8/30 kid rcc as 62.2mg * P<.0005 25.6mg 239.mg 0/45 0/41 2/45 1/38 4/31 thy fcc as 62.9mg * P<.002 25.7mg 350.mg 0/36 2/38 0/42 2/36 6/30 840 R m f3d wat 6m24 1814m 0 6.25mg Kurokawa;gann,78,358364;1987/1986a kid ade e 6.67mg P<.0005 3.08mg 18.8mg 0/19 9/19 kid mix e 6.67mg P<.0005 + 3.08mg 18.8mg 0/19 9/19 per mso e 7.84mg P<.0005 3.50mg 24.7mg 0/19 8/19 thy fct e 11.3mg P<.003 4.57mg 58.1mg 0/19 6/19 kid adc e 79.2mg P<.3 12.9mg n.s.s. 0/19 1/19 841 R m f3d wat 9m24 1814n 0 9.38mg kid mix e 4.81mg P<.0005 + 2.42mg 10.9mg 0/19 14/19 kid ade e 5.57mg P<.0005 2.79mg 12.9mg 0/19 13/19 per mso e 14.0mg P<.002 5.97mg 52.5mg 0/19 7/19 kid adc e 16.9mg P<.003 6.85mg 87.2mg 0/19 6/19 842 R m f3d wat 12m24 1814o 0 12.5mg kid mix e 8.32mg P<.0005 + 3.72mg 23.3mg 0/19 9/14 kid ade e 10.1mg P<.0005 4.41mg 30.2mg 0/19 8/14 per mso e 19.4mg P<.003 7.26mg 103.mg 0/19 5/14 thy fct e 19.4mg P<.003 7.26mg 103.mg 0/19 5/14 kid adc e 35.5mg P<.02 10.7mg n.s.s. 0/19 3/14 843 R m f3d wat 52w52 1814r 0 25.0mg Kurokawa;gann,78,358364;1987/19186a kid ade e 4.98mg P<.002 2.66mg 14.9mg 0/8 15/26 per mso e 25.6mg P<.2 8.84mg n.s.s. 0/8 4/26 844 R m f3d wat 24m24 1814s 0 25.0mg Kurokawa;gann,78,358364;1987/1986a per mso e 12.4mg P<.0005 6.33mg 27.2mg 0/19 15/20 kid mix e 28.7mg P<.0005 + 13.3mg 81.8mg 0/19 9/20 thy fct e 39.8mg P<.002 17.0mg 156.mg 0/19 7/20 kid ade e 48.0mg P<.004 19.4mg 271.mg 0/19 6/20 thy fca e 59.5mg P<.008 22.5mg 895.mg 0/19 5/20 kid adc e 105.mg P<.04 31.8mg n.s.s. 0/19 3/20 845 R m f3d wat 24m24 1851 0 .750mg 1.50mg 3.00mg 6.25mg 12.5mg 25.0mg Kurokawa;jnci,77,977982; 1986a/1987 per mso 19.5mg * P<.0005 12.2mg 41.2mg 0/20 0/20 3/20 4/24 2/24 3/20 15/20 kid rct 28.9mg * P<.0005 + 17.0mg 55.2mg 0/20 0/20 0/20 1/24 5/24 5/20 9/20 kid ade 35.7mg * P<.0005 + 20.2mg 78.3mg 0/20 0/20 0/20 1/24 5/24 5/20 6/20 thy fct e 54.7mg * P<.0005 27.4mg 136.mg 0/16 0/19 0/20 1/24 0/24 3/20 7/19 kid adc 224.mg * P<.006 67.7mg 2.91gm 0/20 0/20 0/20 0/24 0/24 0/20 3/20 liv nnd 53.2mg Z P<.2 15.2mg n.s.s. 2/20 0/20 4/20 7/24 0/24 6/20 (5/20)
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD_{10} (LTD_{10}) are readily calculated from the TD_{50} and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD_{10} values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.