|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|hmo kid lun pro tes||lun||no test||no positive||0.0136m,v||no positive|
|Hamster Target Sites||TD50
|no positive||no positive||no positive|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
CADMIUM CHLORIDE 10108-64-2 996 H f syg inh 60w76 1909m 0 52.5ug Heinrich;expl,37,253-258;1989/pers.comm. lun tum or no dre P=1. - .139mg n.s.s. 0/24 0/24 997 H f syg inh 64w76 1909n 0 18.7ug lun tum or no dre P=1. - 49.3ug n.s.s. 0/24 0/24 998 H m syg inh 14m24 1909m 0 34.5ug lun tum or no dre P=1. - .164mg n.s.s. 0/24 0/24 999 H m syg inh 15m26 1909n 0 11.1ug lun tum or no dre P=1. - 64.6ug n.s.s. 0/24 0/24 1000 M f nmr inh 42w82 1909m 0 75.0ug lun mix eor no dre P=1. - .126mg n.s.s. 11/43 8/41 lun ade eor no dre P=1. - .139mg n.s.s. 8/43 6/41 lun adc eor no dre P=1. - .211mg n.s.s. 3/43 2/41 1001 M f nmr inh 69w89 1909n 0 37.8ug lun ade eor no dre P=1. - .207mg n.s.s. 9/45 1/43 lun mix eor no dre P=1. - .221mg n.s.s. 17/45 1/43 lun adc eor no dre P=1. - .246mg n.s.s. 8/45 0/43 1002 R m nbl wat 24m24 2599 0 2.04mg 4.07mg 8.15mg 16.3mg Waalkes;jtxe,58,199-214;1999/pers.comm. kid mix e 114.mg * P<.008 + 43.1mg 2.34gm 0/29 0/29 0/29 2/30 3/29 kid mmt e 193.mg * P<.08 58.4mg n.s.s. 0/29 0/29 0/29 2/30 1/29 k/p tcc e 584.mg * P<.2 95.1mg n.s.s. 0/29 0/29 0/29 0/30 1/29 kid lip e 584.mg * P<.2 95.1mg n.s.s. 0/29 0/29 0/29 0/30 1/29 adr pbm e 686.mg * P<.9 28.4mg n.s.s. 2/29 3/30 8/30 6/30 3/29 liv tum e no dre P=1. 6.33mg n.s.s. 0/29 0/29 0/30 0/30 0/29 pro tum e no dre P=1. 5.69mg n.s.s. 0/28 0/26 0/26 0/29 0/27 1003 R f wis inh 6m29 1908m 0 11.7ug Oldiges;txec,19,217-222;1989/Glaser 1990 lun mix eor 64.5ug P<.03 19.5ug n.s.s. 0/20 3/18 lun sqa eor 99.8ug P<.08 24.5ug n.s.s. 0/20 2/18 lun adc eor .206mg P<.3 33.5ug n.s.s. 0/20 1/18 1004 R f wis inh 18m31 1908n 0 10.9ug lun mix eor 9.71ug P<.0005 + 4.81ug 22.7ug 0/20 13/18 lun adc eor 25.3ug P<.0005 10.8ug 88.9ug 0/20 7/18 lun a/a eor 49.5ug P<.02 17.0ug n.s.s. 0/20 4/18 lun adq eor .106mg P<.08 25.9ug n.s.s. 0/20 2/18 1005 R m wis inh 18m31 1907 0 3.34ug 6.68ug 13.4ug Takenaka;jnci,70,367-373;1983 lun car eo 12.7ug * P<.0005 + 8.89ug 18.8ug 0/38 6/39 20/38 25/35 lun adc eo 22.0ug * P<.0005 14.6ug 35.9ug 0/38 4/39 16/38 15/35 lun epc eo 58.8ug * P<.0005 32.3ug .158mg 0/38 2/39 5/38 8/35 lun mec eo .315mg * P<.03 95.5ug n.s.s. 0/38 0/39 0/38 3/35 lun ade eo .563mg * P<.5 .118mg n.s.s. 0/38 1/39 0/38 1/35 adr pbm eo .591mg * P<.8 49.7ug n.s.s. 2/38 8/39 4/38 4/35 1006 R m wis inh 6m30 1908m 0 7.91ug Oldiges;txec,19,217-222;1989/Glaser 1990 lun mix eor 10.6ug P<.0005 + 5.19ug 26.3ug 0/40 11/20 lun adc eor 29.4ug P<.002 11.1ug .128mg 0/40 5/20 lun a/a eor 52.1ug P<.01 15.7ug 2.57mg 0/40 3/20 lun sqa eor 52.1ug P<.01 15.7ug 2.57mg 0/40 3/20 1007 R m wis inh 18m30 1908n 0 7.91ug lun mix eor 6.11ug P<.0005 + 3.13ug 13.5ug 0/40 15/20 lun adc eor 9.24ug P<.0005 4.61ug 22.1ug 0/40 12/20 lun a/a eor 80.4ug P<.04 19.8ug n.s.s. 0/40 2/20 lun adq eor .165mg P<.2 26.9ug n.s.s. 0/40 1/20 1008 R m wis eat 77w77 2027 0 1.63mg 3.26mg 6.52mg 13.0mg Waalkes;faat,19,512-520;1992/pers.comm. tes icb e 31.6mg * P<.03 + 12.1mg n.s.s. 1/28 2/27 1/25 1/24 6/27 pro ade e 56.9mg * P<.3 + 15.3mg n.s.s. 0/28 1/26 2/22 1/23 2/26 --- lle e no dre P=1. + 16.9mg n.s.s. 1/28 4/27 5/24 5/24 1/27 1009 R m wis wat 78w78 2658 0 4.00mg Martin;prst,46,11-20;2001 prv tum Cer no dre P=1. 4.64mg n.s.s. 0/10 0/10
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.