|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|liv||liv mgl||adr liv||adr liv||27.8m||33.6m,v|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
CARBON TETRACHLORIDE 56-23-5 1105 M f b6c gav 78w90 1469m 0 774.mg 1.55gm Weisburger;enhp,21,7-16;1977/National Cancer Institute 1976 liv hpc ej 184.mg * P<.0005 + 119.mg 287.mg 1/18 40/42 43/45 adr mix ej 899.mg \ P<.0005 + 490.mg 2.35gm 0/18 15/42 (10/45) tba mix ej 195.mg * P<.0005 123.mg 324.mg 3/18 40/42 43/45 1106 M m b6c gav 78w90 1469m 0 774.mg 1.55gm liv hpc ej 127.mg * P<.0005 + 70.1mg 220.mg 3/18 49/49 47/48 adr mix ej 683.mg * P<.0005 + 487.mg 1.21gm 0/18 28/49 28/48 tba mix ej 130.mg * P<.0005 70.9mg 230.mg 4/18 49/49 47/48 1107 M f bdj inh 24m24 2378 0 9.84mg 49.2mg 246.mg Nagano;apor,741-746;1998/pers.comm. liv mix e 25.2mg * P<.0005 + 17.1mg 38.9mg 4/50 9/49 44/50 48/49 liv hpc e 41.9mg Z P<.0005 + 27.0mg 70.5mg 2/50 1/49 33/50 (48/49) liv hpa e 85.4mg Z P<.0005 + 46.4mg 265.mg 2/50 8/49 17/50 (5/49) adr phe e 377.mg Z P<.0005 + 226.mg 692.mg 0/50 0/49 0/50 22/49 lun a/c e 46.1gm * P<1. 1.33gm n.s.s. 2/50 2/49 1/50 2/49 lun a/a e no dre P=1. 2.72gm n.s.s. 4/50 2/49 1/50 0/49 1108 M m bdj inh 24m24 2378 0 8.20mg 41.0mg 205.mg liv mix e 15.1mg * P<.0005 + 8.96mg 29.2mg 24/50 20/50 48/50 50/50 liv hpc e 34.0mg * P<.0005 + 21.1mg 59.8mg 17/50 12/50 42/50 48/50 liv hpa e 50.2mg Z P<.0005 + 28.1mg 135.mg 9/50 9/50 27/50 (16/50) adr phe e 126.mg * P<.0005 + 86.8mg 190.mg 0/50 0/50 16/50 31/50 lun a/a e no dre P=1. 1.68gm n.s.s. 2/50 5/50 1/50 1/50 lun a/c e no dre P=1. 48.2mg n.s.s. 11/50 4/50 (3/50 0/50) 1109 R f f3d inh 24m24 2378 0 2.34mg 11.7mg 58.6mg liv mix e 29.8mg Z P<.0005 + 20.3mg 45.6mg 0/50 0/50 3/50 44/50 liv hpa e 38.7mg Z P<.0005 + 25.9mg 61.0mg 0/50 0/50 0/50 40/50 sub mix e 65.2mg Z P<.003 28.2mg 329.mg 0/50 1/50 6/50 (0/50) liv hpc e 120.mg * P<.0005 + 68.9mg 236.mg 0/50 0/50 3/50 15/50 adr phe e no dre P=1. 148.mg n.s.s. 8/50 12/50 19/50 10/50 adr mix e no dre P=1. 155.mg n.s.s. 9/50 12/50 20/50 10/50 1110 R m f3d inh 24m24 2378 0 1.64mg 8.20mg 41.0mg liv mix e 26.0mg Z P<.0005 + 17.4mg 40.8mg 1/50 1/50 1/50 40/50 liv hpc e 39.1mg Z P<.0005 + 25.2mg 65.1mg 1/50 0/50 0/50 32/50 liv hpa e 61.8mg * P<.0005 + 37.5mg 112.mg 0/50 1/50 1/50 21/50 1111 R f nss ivj 47w69 1515 0 .157mg Tourkevitch;ijcn,20,1446-1449;1964 liv tum .877mg P<.1 .265mg n.s.s. 0/34 3/57 mgl mix .765mg P<.3 + .214mg n.s.s. 1/34 5/57 tba mix .176mg P<.007 87.0ug 2.27mg 2/34 16/57 1112 R f osm gav 18m26 1469n 0 40.5mg 81.0mg Weisburger;enhp,21,7-16;1977/National Cancer Institute 1976 liv nnd ej 390.mg * P<.3 + 140.mg n.s.s. 1/20 11/50 9/49 liv hpc ej no dre P=1. 415.mg n.s.s. 1/20 4/50 2/49 tba mix ej no dre P=1. 144.mg n.s.s. 10/20 34/50 20/49 1113 R m osm gav 18m26 1469n 0 23.8mg 47.6mg liv nnd ej 529.mg * P<.2 + 201.mg n.s.s. 0/20 2/49 3/50 liv hpc ej 666.mg * P<.4 230.mg n.s.s. 0/20 2/49 2/50 tba mix ej 166.mg * P<.4 48.7mg n.s.s. 7/20 21/49 24/50
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.