|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|kid hed tes||hed kid||lun||liv||72.6m,v||1600m|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
ETHYLBENZENE 100-41-4 2723 M f b6c inh 24m24 TR466 : 0 101.mg 336.mg 1.01gm liv MXA 1.88gm * P<.02 p 809.mg n.s.s. 13/50 12/50 15/50 25/50 liv:hpa,hpc. liv hpa 2.45gm * P<.04 978.mg n.s.s. 6/50 9/50 12/50 16/50 S hag ade 9.07gm * P<.02 3.13gm n.s.s. 0/50 0/50 1/50 3/50 S TBA MXB 4.07gm * P<.6 769.mg n.s.s. 29/50 38/50 31/50 38/50 liv MXB 1.88gm * P<.02 809.mg n.s.s. 13/50 12/50 15/50 25/50 liv:hpa,hpb,hpc. lun MXB 7.95gm * P<.4 1.91gm n.s.s. 4/50 6/50 5/50 8/50 lun:a/a,a/c. 2724 M m b6c inh 24m24 TR466 : 0 84.3mg 281.mg 843.mg lun MXA 1.40gm * P<.02 p 614.mg n.s.s. 7/50 10/50 15/50 19/50 lun:a/a,a/c. lun a/a 1.68gm * P<.02 716.mg n.s.s. 5/50 9/50 10/50 16/50 S TBA MXB 2.01gm * P<.4 493.mg n.s.s. 35/50 34/50 40/50 41/50 liv MXB 9.31gm * P<.8 787.mg n.s.s. 27/50 24/50 30/50 27/50 liv:hpa,hpb,hpc. lun MXB 1.40gm * P<.02 614.mg n.s.s. 7/50 10/50 15/50 19/50 lun:a/a,a/c. 2725 R f f34 inh 24m24 TR466 : 0 24.1mg 80.4mg 242.mg kid rua 8.25gm * P<.2 1.34gm n.s.s. 0/50 0/50 0/50 1/50 TBA MXB no dre P=1. 185.mg n.s.s. 42/50 45/50 43/50 46/50 liv MXB no dre P=1. n.s.s. n.s.s. 0/50 0/50 0/50 0/50 liv:hpa,hpb,hpc. 2726 R f f34 inh 24m24 TR466 with step 0 24.1mg 80.4mg 242.mg kid rua 1.26gm * P<.0005 p 595.mg 3.49gm 0/50 0/50 1/50 8/50 2727 R m f34 inh 24m24 TR466 : 0 16.9mg 56.4mg 169.mg tes iab 23.1mg Z P<.0005 13.8mg 47.2mg 27/50 23/50 32/50 40/50 S MXB MXB 24.6mg * P<.0005 14.2mg 55.2mg 36/50 34/50 40/50 45/50 kid:rua,ruc; tes:iab,ica. C tes MXA 24.8mg * P<.0005 c 14.3mg 56.3mg 36/50 33/50 40/50 44/50 tes:iab,ica. amd MXA 106.mg Z P<.009 42.3mg 3.83gm 13/50 13/50 9/50 14/50 amd:pbb,phm,pob. S kid MXA 147.mg * P<.0005 c 64.1mg 612.mg 0/50 3/50 3/50 7/50 kid:rua,ruc. kid rua 232.mg * P<.01 c 80.8mg 23.5gm 0/50 3/50 2/50 4/50 kid ruc 553.mg * P<.005 137.mg 6.47gm 0/50 0/50 1/50 3/50 S amd MXA 125.mg * P<.03 45.4mg n.s.s. 13/50 13/50 9/50 12/50 amd:pbb,pob. S TBA MXB 53.0mg * P<.008 23.5mg 1.21gm 48/50 44/50 47/50 38/50 liv MXB no dre P=1. 835.mg n.s.s. 0/50 3/50 0/50 0/50 liv:hpa,hpb,hpc. 2728 R m f34 inh 24m24 TR466 with step 0 16.9mg 56.4mg 169.mg kid MXA 255.mg * P<.0005 c 150.mg 585.mg 3/50 5/50 8/50 21/50 kid:rua,ruc. kid rua 280.mg * P<.0005 c 161.mg 680.mg 3/50 5/50 7/50 20/50 kid ruc 2.03gm * P<.02 701.mg n.s.s. 0/50 0/50 1/50 3/50 S 2729 R f sda gav 24m29 BT912 0 387.mg Maltoni;anya,837,15-52;1997 hed car h 4.17gm P<.2 + 1.24gm n.s.s. 3/50 7/50 orc car 8.89gm P<.3 1.96gm n.s.s. 1/50 3/50 nas car 18.3gm P<.3 2.99gm n.s.s. 0/50 1/50 nas ene 18.3gm P<.3 2.99gm n.s.s. 0/50 1/50 edu car no dre P=1. 3.39gm n.s.s. 1/50 1/50 zym car no dre P=1. 3.39gm n.s.s. 1/50 1/50 tba mal 1.61gm P<.08 605.mg n.s.s. 11/50 19/50 tba mix no dre P=1. 769.mg n.s.s. 35/50 30/50 2730 R f sda gav 24m33 BT905m 0 237.mg Maltoni;ajim,7,415-446;1985/1997a tba mal ej 1.21gm P<.08 433.mg n.s.s. 10/49 14/37 tba mix j 635.mg P<.2 211.mg n.s.s. 30/50 30/40 2731 R m sda gav 24m29 BT912 0 387.mg Maltoni;anya,837,15-52;1997 hed car h 4.35gm P<.08 + 1.42gm n.s.s. 1/50 5/50 nas ene 5.99gm P<.04 1.81gm n.s.s. 0/50 3/50 edu car 18.3gm P<.3 2.99gm n.s.s. 0/50 1/50 orc car 18.3gm P<.3 2.99gm n.s.s. 0/50 1/50 zym car no dre P=1. 5.57gm n.s.s. 1/50 0/50 tba mal no dre P=1. 1.20gm n.s.s. 12/50 12/50 tba mix no dre P=1. 1.04gm n.s.s. 27/50 22/50 2732 R m sda gav 24m33 BT905m 0 237.mg Maltoni;ajim,7,415-446;1985/1997a tba mix j 1.16gm P<.4 282.mg n.s.s. 29/50 27/40 tba mal ej 1.98gm P<.3 528.mg n.s.s. 11/45 14/40
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.