|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|kid liv mgl||ezy hmo kid lgi liv mgl smi||no test||hmo sto||5.06m||10.8m|
|Hamster Target Sites||TD50
|sto ubl||no test||16.6|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
FORMIC ACID 2-[4-(5-NITRO-2-FURYL)-2-THIAZOLYL]HYDRAZIDE (FNT) 3570-75-0 2919 H m syg eat 48w70 1077 0 63.1mg Croft;jnci,51,941-949;1973 ubl tcc e 16.6mg P<.0005 + 7.32mg 46.9mg 0/17 9/13 for sqp e 25.1mg P<.0005 + 12.9mg 57.3mg 0/24 13/24 liv tum e no dre P=1. 141.mg n.s.s. 0/24 0/24 lun tum e no dre P=1. 141.mg n.s.s. 0/24 0/24 2920 M f swi eat 33w52 1076 0 41.3mg Cohen;canr,33,1593-1597;1973 for sqp e 8.85mg P<.0005 + 4.33mg 21.9mg 0/29 11/20 --- lle e 11.4mg P<.0005 + 5.09mg 47.4mg 2/29 10/20 lun alc e 67.1mg P<.06 16.5mg n.s.s. 0/29 2/20 liv tum e no dre P=1. 42.5mg n.s.s. 0/29 0/20 tba mix e 2.42mg P<.0005 .980mg 5.76mg 2/29 19/20 2921 M f swi eat 33w52 1118 0 41.3mg Cohen;canr,38,1398-1405;1978 for pam 13.8mg P<.0005 + 7.06mg 32.6mg 0/30 12/30 --- leu 25.6mg P<.008 10.7mg 639.mg 1/30 8/30 liv tum no dre P=1. 63.8mg n.s.s. 0/30 0/30 lun tum no dre P=1. 63.8mg n.s.s. 0/30 0/30 2922 R f buf eat 46w64 1073 0 71.9mg Erturk;jnci,47,437-445;1971/1970a mgl mix e 5.54mg P<.0005 + 2.43mg 11.4mg 0/30 28/29 mgl adc e 13.1mg P<.0005 + 7.48mg 25.0mg 0/30 22/29 kid mix e 17.5mg P<.0005 + 9.87mg 34.5mg 0/30 19/29 liv cye e 39.1mg P<.0005 + 19.5mg 96.4mg 0/30 11/29 kid uac e 44.1mg P<.0005 + 21.3mg 116.mg 0/30 10/29 mgl adf e 80.5mg P<.003 + 32.7mg 434.mg 0/30 6/29 kid tua e 98.6mg P<.007 + 37.3mg 1.20gm 0/30 5/29 tba mix e noTD50 P<.0005 n.s.s. 8.39mg 0/30 29/29 2923 R f hza eat 44w60 1063 0 73.6mg Morris;canr,29,2145-2156;1969 mam tum es 5.50mg P<.0005 + 2.28mg 13.1mg 3/16 25/26 kid ade es 17.6mg P<.0005 + 9.51mg 37.0mg 0/16 16/26 kid car es 78.5mg P<.03 + 29.7mg n.s.s. 0/16 5/26 smi adc es 78.5mg P<.03 + 29.7mg n.s.s. 0/16 5/26 eac sqc esh 100.mg P<.05 + 34.6mg n.s.s. 0/16 4/26 cec adc es 210.mg P<.2 + 51.5mg n.s.s. 0/16 2/26 liv hms es 428.mg P<.4 - 69.6mg n.s.s. 0/16 1/26 2924 R f sda eat 45w75 200a 0 31.3mg Cohen;jnci,51,403-417;1973 mgl adc ev 3.54mg P<.0005 + 1.95mg 6.19mg 6/71 49/51 for sqp ev 65.4mg P<.0005 29.6mg 196.mg 0/71 8/51 kid rcc ev 65.4mg P<.0005 29.6mg 196.mg 0/71 8/51 k/p tcc evh 137.mg P<.008 + 47.2mg 3.07gm 0/71 4/51 --- lbl evh 184.mg P<.03 + 55.7mg n.s.s. 0/71 3/51 liv tum ev no dre P=1. - 171.mg n.s.s. 0/71 0/51 tba mix ev 3.79mg P<.0005 2.02mg 7.04mg 18/71 49/51 2925 R f sda eat 46w64 1073 0 71.9mg Erturk;jnci,47,437-445;1971/1970a mgl mix e 5.85mg P<.0005 + 2.49mg 12.8mg 2/29 25/26 kid mix e 9.96mg P<.0005 + 5.42mg 19.5mg 0/29 22/26 mgl adc e 19.5mg P<.0005 + 10.6mg 41.0mg 0/29 16/26 liv mix e 30.1mg P<.0005 + 15.3mg 71.1mg 0/29 12/26 kid uac e 33.9mg P<.0005 + 16.8mg 83.4mg 0/29 11/26 liv cye e 43.9mg P<.0005 + 20.5mg 123.mg 0/29 9/26 kid tua e 50.7mg P<.0005 + 22.8mg 157.mg 0/29 8/26 mgl adf e 52.8mg P<.009 + 22.0mg 2.37gm 2/29 9/26 tba mix e noTD50 P<.0005 n.s.s. 9.13mg 2/29 26/26 2926 R m sda eat 46w64 1073 0 57.5mg kid mix er 5.82mg P<.0005 + 2.92mg 11.7mg 0/28 24/26 kid uac er 19.3mg P<.0005 + 10.2mg 42.6mg 0/28 14/26 liv cye e 35.3mg P<.0005 + 17.1mg 92.9mg 0/29 10/29 mgl adf eh 46.2mg P<.0005 + 20.8mg 151.mg 0/29 8/29 kid tua er 47.6mg P<.002 + 20.4mg 177.mg 0/28 7/26 k/p tcc er 69.9mg P<.006 + 26.4mg 690.mg 0/28 5/26 tba mix e noTD50 P<.0005 n.s.s. 6.71mg 0/29 29/29
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.