|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
|no positive||no positive||no positive||no positive||no positive||no positive|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
HYDROCHLOROTHIAZIDE 58-93-5 3222 M f b6c eat 24m24 TR357 : 0 320.mg 638.mg TBA MXB no dre P=1. - 846.mg n.s.s. 36/50 35/50 27/50 liv MXB no dre P=1. 2.74gm n.s.s. 3/50 5/50 1/50 liv:hpa,hpc,nnd. lun MXB no dre P=1. 3.18gm n.s.s. 4/50 3/50 2/50 lun:a/a,a/c. 3223 M m b6c eat 24m24 TR357 : 0 296.mg 589.mg liv MXA 1.23gm * P<.008 e 612.mg 24.4gm 7/50 10/50 21/50 liv:hpa,hpc. liv hpa 1.49gm * P<.007 747.mg 20.3gm 3/50 8/50 14/50 S TBA MXB 3.82gm / P<.7 610.mg n.s.s. 30/50 20/50 34/50 liv MXB 1.23gm * P<.008 612.mg 24.4gm 7/50 10/50 21/50 liv:hpa,hpc,nnd. lun MXB 19.8gm * P<.9 1.59gm n.s.s. 8/50 4/50 9/50 lun:a/a,a/c. 3224 R f f34 eat 24m25 TR357 : 0 12.4mg 24.6mg 99.1mg TBA MXB no dre P=1. - 88.0mg n.s.s. 49/50 39/50 39/50 37/50 liv MXB no dre P=1. n.s.s. n.s.s. 0/50 0/50 0/50 0/50 liv:hpa,hpc,nnd. 3225 R f f34 eat 24m30 1854 0 44.0mg Lijinsky;txih,3,413-422;1987/pers.comm. pit mix 33.9mg P<.0005 18.4mg 69.4mg 0/24 18/24 adr phe 100.mg P<.0005 46.7mg 285.mg 0/24 9/24 liv hpc 1.11gm P<.3 180.mg n.s.s. 0/24 1/24 liv mix no dre P=1. 152.mg n.s.s. 4/24 3/24 liv nnd no dre P=1. 194.mg n.s.s. 4/24 2/24 3226 R m f34 eat 24m25 TR357 : 0 9.91mg 19.8mg 79.2mg TBA MXB 214.mg * P<.7 - 29.2mg n.s.s. 50/50 43/50 44/50 45/50 liv MXB 771.mg * P<.3 143.mg n.s.s. 1/50 0/50 1/50 2/50 liv:hpa,hpc,nnd. 3227 R m f34 eat 24m30 1854 0 46.2mg Lijinsky;txih,3,413-422;1987/pers.comm. tes car 35.6mg P<.0005 19.3mg 72.9mg 0/24 18/24 pit mix 71.3mg P<.0005 36.1mg 169.mg 0/24 12/24 adr phe 271.mg P<.4 64.1mg n.s.s. 6/24 9/24 liv hpc no dre P=1. 357.mg n.s.s. 1/24 0/24 liv mix no dre P=1. 357.mg n.s.s. 3/24 0/24 liv nnd no dre P=1. 357.mg n.s.s. 2/24 0/24
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.