|Rat Target Sites||Mouse Target Sites||TD50 (mg/kg/day)|
Key to the Table Above
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD50 estimation for a standard lifespan. See Methods for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.
Chemical (Synonym) CAS # Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
STYRENE OXIDE 96-09-3 5750 M f b6c gav 24m25 1791 0 155.mg 311.mg Lijinsky;jnci,77,471-476;1986 for mix e 172.mg \ P<.0005 + 105.mg 309.mg 0/51 24/50 (20/51) for sqp e 460.mg * P<.0005 + 298.mg 775.mg 0/51 14/50 17/51 for sqc e 505.mg \ P<.0005 + 246.mg 1.35gm 0/51 10/50 (3/51) liv mix e 5.96gm * P<.6 969.mg n.s.s. 7/51 4/50 9/51 5751 M m b6c gav 24m25 1791 0 155.mg 311.mg for mix e 90.0mg \ P<.0005 + 57.8mg 150.mg 2/51 37/51 (21/52) for sqp e 215.mg \ P<.0005 + 124.mg 458.mg 2/51 22/51 (8/52) liv mix e 223.mg \ P<.002 113.mg 1.17gm 12/51 28/52 (15/52) for sqc e 475.mg * P<.0005 + 308.mg 828.mg 0/51 16/51 15/52 5752 R f f34 gav 24m25 1791 0 114.mg 228.mg for mix e 42.9mg * P<.0005 + 29.8mg 61.7mg 0/52 46/52 50/52 for sqc e 114.mg * P<.0005 + 83.0mg 161.mg 0/52 32/52 36/52 for sqp e 217.mg * P<.0005 + 150.mg 328.mg 0/52 21/52 24/52 liv nnd e no dre P=1. 472.mg n.s.s. 8/52 6/52 (0/52) 5753 R m f34 gav 24m25 1791 0 114.mg 228.mg for mix e 30.7mg * P<.0005 + 19.4mg 47.0mg 1/52 50/52 50/51 for sqc e 81.6mg * P<.0005 + 59.6mg 114.mg 0/52 35/52 43/51 for sqp e 146.mg \ P<.0005 + 87.2mg 283.mg 1/52 23/52 (18/51) liv nnd e 10.3gm * P<.7 1.33gm n.s.s. 2/52 1/52 3/52 5754 R f sda gav 12m36 BT105 0 10.7mg 53.6mg Conti;anya,534,203-234;1988 for mix ej 96.5mg * P<.0005 + 60.6mg 167.mg 0/40 7/37 21/38 for sqc ej 102.mg * P<.0005 + 63.7mg 180.mg 0/40 7/37 20/38 for sqn ej 129.mg * P<.0005 + 78.0mg 264.mg 0/40 7/37 16/38 for sqi ej 301.mg * P<.0005 + 151.mg 755.mg 0/40 1/37 10/38 for ben ej 503.mg * P<.009 + 217.mg 19.7gm 0/40 2/37 5/38 tba mix j 164.mg * P<.009 74.1mg 7.47gm 10/40 16/40 22/40 tba mal j 166.mg * P<.002 83.2mg 771.mg 7/40 9/40 20/40 5755 R f sda gav 12m36 1702 0 10.7mg 53.6mg Maltoni;amet,2,97-110;1981 for mix er 96.5mg * P<.0005 + 60.6mg 167.mg 0/40 7/37 21/38 for sqc er 102.mg * P<.0005 + 63.7mg 180.mg 0/40 7/37 20/38 for sqn er 129.mg * P<.0005 + 78.0mg 264.mg 0/40 7/37 16/38 for sqi er 301.mg * P<.0005 + 151.mg 755.mg 0/40 1/37 10/38 for ben er 503.mg * P<.009 + 217.mg 19.7gm 0/40 2/37 5/38 5756 R m sda gav 12m36 BT105 0 10.7mg 53.6mg Conti;anya,534,203-234;1988 for sqc ej 63.0mg \ P<.0005 + 29.6mg 184.mg 0/39 9/39 (16/39) for mix ej 99.6mg * P<.0005 + 63.2mg 194.mg 0/39 10/39 19/39 for sqn ej 140.mg * P<.0005 + 84.3mg 284.mg 0/39 6/39 16/39 for sqi ej 267.mg * P<.004 + 141.mg 2.30gm 0/39 5/39 8/39 for ben ej 354.mg * P<.003 + 172.mg 2.23gm 0/39 3/39 7/39 tba mal j 189.mg * P<.004 89.2mg 1.75gm 6/40 11/40 18/40 tba mix j 191.mg * P<.02 84.0mg n.s.s. 9/40 14/40 20/40 5757 R m sda gav 12m36 1702 0 10.7mg 53.6mg Maltoni;amet,2,97-110;1981 for sqc er 63.0mg \ P<.0005 + 29.6mg 184.mg 0/39 9/39 (16/39) for mix er 99.6mg * P<.0005 + 63.2mg 194.mg 0/39 10/39 19/39 for sqn er 140.mg * P<.0005 + 84.3mg 284.mg 0/39 6/39 16/39 for sqi er 267.mg * P<.004 + 141.mg 2.30gm 0/39 5/39 8/39 for ben er 354.mg * P<.003 + 172.mg 2.23gm 0/39 3/39 7/39
See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.
A Supplementary Dataset gives details on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the TD10 (LTD10) are readily calculated from the TD50 and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD10 values, we provide them in an Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.